Korean J Anesthesiol.  1994 Nov;27(11):1686-1691. 10.4097/kjae.1994.27.11.1686.

Two Case Reports of Seizure Following Inadvertent Injection of Tranexamic Acid into Subarachnoid Space

• Jung YC
• Lee SH
• Lee CS
• Kim WT

• KMID: 2236941
• DOI: http://doi.org/10.4097/kjae.1994.27.11.1686

Abstract

We experienced two cases of convulsive seizure, accompanied with tachycardia and hypertension following spinal anesthesia for inguinal herniorrhaphy and skin graft. Spinal anesthesia was performed with teracaine, 10% dextrose solution and epinephrine. Tranexamic acid was used instead of 10% dextrose solution inadvertently. About 2 hours after spinal anesthesia, the patients developed spastic rigidity at the upper extremities and chest wall that progressed to episthotonus and seizure preceded by tachycardia and hypertension. About 40 hours after vigorous symptomatic treatment using mechanical ventilator, oxygen, short acting barbiturate, antihypertensive drugs and anticonvulsants, the patients had recovered completely with clear mental state. And they didn't show any other neurologic deficits except amnesia.

Keyword

Seizure; Inadvertent injection; Subarachnoid space; Tranexamic acid

MeSH Terms

Amnesia
Anesthesia, Spinal
Anticonvulsants
Antihypertensive Agents
Epinephrine
Glucose
Herniorrhaphy
Humans
Hypertension
Muscle Spasticity
Neurologic Manifestations
Oxygen
Seizures*
Skin
Subarachnoid Space*
Tachycardia
Thoracic Wall
Tranexamic Acid*
Transplants
Upper Extremity
Ventilators, Mechanical
Anticonvulsants
Antihypertensive Agents
Epinephrine
Glucose
Oxygen
Tranexamic Acid