Korean J Anesthesiol.  1996 Dec;31(6):771-776. 10.4097/kjae.1996.31.6.771.

Epidural Nalbuphine Reduces the Side Effects from Epidural Morphine after Cesarean Section

• Ahn JC
• Lee SK
• Han IS
• Jang SC

• KMID: 2236911
• DOI: http://doi.org/10.4097/kjae.1996.31.6.771

Abstract

BACKGROUND: This study was undertaken to reduce the side effects of epidural morphine through the addition of nalbuphine in 37 cesarean delivery.
METHODS
Forty patients were divided into 2 groups; M(control) group: bolus administration of morphine 2 mg in 0.5% bupivacaine and continuous epidural 41 hour-infusion of morphine 7mg, N(experimental) group: bolus administration of morphine 2 mg in 0.5% bupivacaine combined with nalbuphine 10mg and continuous epidural 41 hour-infusion of morphine 7mg combined with nalbuphine 10mg via the Paragon infusor.
RESULTS
During the postoperative 48 hours, their pain scores and side effects were recorded at 6, 12, 18, 24, 30, 36, 42 and 48 hours. The analgesic effects were good in two groups(mean VAS <3.0) and pain scores were statistically significant at 18 and 30 hour. The incidence of pruritus, nausea, vomiting and urinary retention was decreased in group N(p<0.05).
CONCLUSIONS
We concluded that continuous epidural morphine combined with nalbuphine was one of recommendable methods to reduce side effects of morphine.

Keyword

Analgesia postoperative; Analgesics morphine; nalbuphine; Anesthetic techniques epidural

MeSH Terms

Bupivacaine
Cesarean Section*
Female
Humans
Incidence
Infusion Pumps
Morphine*
Nalbuphine*
Nausea
Pregnancy
Pruritus
Urinary Retention
Vomiting
Bupivacaine
Morphine
Nalbuphine