Korean J Anesthesiol.  1996 Dec;31(6):665-676. 10.4097/kjae.1996.31.6.665.

The Hemodynamic Effects of Esmolol and Propranolol in Isoflurane-Anesthetized Dogs

• Lee SC
• Kim YL
• Lee C

• KMID: 2236897
• DOI: http://doi.org/10.4097/kjae.1996.31.6.665

Abstract

BACKGROUNDS: This study was to evaluate the hemodynamic effects of esmolol and propranolol in the isoflurane-anesthetized dogs.
METHODS
Ten dogs were anesthetized with isoflurane, N2O and O2. The hemodynamic parameters were measured as control values and were also measured after 500, 1000, 2000 microgram/kg of esmolol and 0.25, 0.5, 1.0 mg of propranolol were bolus injected intravenously.
RESULTS
Heart rate and cardiac output were significantly decreased in both groups compared with control value, but there were no significant differences between two groups. Blood pressure was significantly decreased in the dosage of 1000, 2000 microgram/kg of esmolol group compared with control value and propranolol group, but in propranolol group, no significant changes were found. Systemic and pulmonary vascular resistance were not changed significantly in both groups compared to control value, but in propranolol group, SVR was significantly increased in the dosage of 0.5 and 1.0 mg compared with esmolol group. Central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, arterial and mixed venous blood pH, oxygen tension, CO2 tension and O2 saturation were not significantly changed and O2 flux, O2 consumption, O2 extraction ratio were also unchanged.
CONCLUSIONS
In conclusion, esmolol and propranolol of the usual dosages are less likely to depress the myocardium profoundly during isoflurane anesthesia, and esmolol, compared to propranolol, decreases the blood pressure but changes 2 of cardiac output were not significant between two groups, so it can be used in the hypertensive state or induced hypotensive anesthesia usefully and can also be used conveniently during anesthesia because of its ease of controllability.

Keyword

Anesthetics; volatile isoflurane; Sympathetic nervous system esmolol; propranolol

MeSH Terms

Anesthesia
Anesthetics
Animals
Arterial Pressure
Blood Pressure
Cardiac Output
Central Venous Pressure
Dogs*
Heart Rate
Hemodynamics*
Hydrogen-Ion Concentration
Isoflurane
Myocardium
Oxygen
Propranolol*
Pulmonary Wedge Pressure
Vascular Resistance
Anesthetics
Isoflurane
Oxygen
Propranolol