Korean J Anesthesiol.  2002 Apr;42(4):472-477. 10.4097/kjae.2002.42.4.472.

The Analgesic Effects of Caudal Morphine and Meperidine Containing Bupivacaine in Pediatric Open Heart Surgery

• Sim JY
• Huh IY
• Choi SK
• Choi IC

• KMID: 2236782
• DOI: http://doi.org/10.4097/kjae.2002.42.4.472

Abstract

BACKGROUND: In both infants and children, increased hormonal and metabolic responses to open heart surgery may be directly related to postoperative complications. Anesthestic management including regional anesthesia can substantially attenuate a perioperative stress response and targeted therapy may improve the outcome. In this study, our objectives were to quantify the extent of pain control, and to evaluate the safety and efficacy of caudal morphine or meperidine.
METHODS
Seventy-five pediatric patients undergoing a open heart surgery were randomly assigned to three groups according to receiving morphine (group M, n = 25), or meperidine (group D, n = 25) caudally, and a control group (group C). Caudal morphine 30ng/kg with 0.15% bupivacaine 1 ml/kg or meperidine 2 mg/kg with 0.15% bupivacaine 1 ml/kg was injected after anesthetic induction. Pain score and side effects were evaluated immediate postoperatively, 12, 24, and 48 hr postoperatively in the intensive care unit and consciousness recovery and extubation time were checked.
RESULTS
Patients in the groups M and D had significantly lower pain scores than the group C. Recovery and extubation time were shorter in the groups M and D. Incidence of nausea and vomiting was significantly higher in the group M than in the groups D and C.
CONCLUSIONS
Caudal morphine and meperidine reduced postoperative pain and facilitated extubation.

Keyword

Bupivacaine; caudal epidural; meperidine; morphine; pediatric open heart surgery

MeSH Terms

Anesthesia, Conduction
Bupivacaine*
Child
Consciousness
Heart*
Humans
Incidence
Infant
Intensive Care Units
Meperidine*
Morphine*
Nausea
Pain, Postoperative
Postoperative Complications
Thoracic Surgery*
Vomiting
Bupivacaine
Meperidine
Morphine