Korean J Anesthesiol.  2007 Jan;52(1):49-54. 10.4097/kjae.2007.52.1.49.

Reevaluation of Thiopental and Propofol using Bispectral Index in the Early Period of Cesarean Section

• Lee HJ
• Chon JY

• KMID: 2236642
• DOI: http://doi.org/10.4097/kjae.2007.52.1.49

Abstract

BACKGROUND
Patients undergoing a cesarean section are at risk of experiencing intra-operative awareness. Thiopental and propofol are both commonly used to induce anesthesia in patients undergoing a cesarean section. This study compared the effect of propofol and thiopental on the anesthetic adequacy of parturients who received inhalation anesthetics using the bispectral index (BIS) in the early period of a cesarean section.
METHODS
Forty-five parturients were randomly assigned to receive either thiopental 4 mg/kg or propofol 2 mg/kg followed by 1% isoflurane with 50% N2O. The BIS, systolic and diastolic arterial pressure, heart rate, and the end-tidal concentration of isoflurane were recorded every minute for 10 minutes after intubation. The apgar score at 1 and 5 minutes and cord blood gas were assessed.
RESULTS
The systolic and diastolic pressure immediately after intubation were significantly lower in the Propofol group than in the Thiopental group. All the BIS values from 0 to 9 minutes after intubation were significantly lower in the Propofol group than in the Thiopental group. The Apgar scores and umbilical cord blood gas analysis were similar both groups.
CONCLUSIONS
These results suggest that propofol is more suitable for the anesthetic adequacy and intraoperative awareness in the early period of a cesarean section than thiopental.

Keyword

awareness; bispectral index; cesarean section; isoflurane; propofol; thiopental

MeSH Terms

Anesthesia
Anesthetics, Inhalation
Apgar Score
Arterial Pressure
Blood Pressure
Cesarean Section*
Female
Fetal Blood
Heart Rate
Humans
Intraoperative Awareness
Intubation
Isoflurane
Pregnancy
Propofol*
Thiopental*
Anesthetics, Inhalation
Isoflurane
Propofol
Thiopental