Korean J Anesthesiol.  2010 Jul;59(1):22-26. 10.4097/kjae.2010.59.1.22.

The effect of intravenous low dose ketamine for reducing postoperative sore throat

• Park SY
• Kim SH
• Noh JI
• Lee SM
• Kim MG
• Kim SH
• Ok SY
• Kim SI

• KMID: 2236483
• DOI: http://doi.org/10.4097/kjae.2010.59.1.22

Abstract

BACKGROUND
This study was performed to evaluate the effectiveness of intravenous low dose ketamine for reducing the incidence and severity of postoperative sore throat (POST).
METHODS
This was a prospective, randomized, double-blind clinical trial. The study population consisted of 70 patients between 20 and 70 years old who were classified as American Society of Anesthesiologists I-II and were scheduled for elective laparoscopic cholecystectomy. The patients were divided randomly into two groups. Patients in the ketamine group received an intravenous injection of 0.5 mg/kg of ketamine just before induction, followed by 10 microgram/kg/min throughout the operation. Patients in the control group received intravenous saline instead of ketamine. The patients were interviewed 1, 6, and 24 h after the operation. The incidence and severity of POST were recorded.
RESULTS
No significant differences in the incidence and severity of POST during the 24 h after the operation were found between the two groups (21/31 in the ketamine group vs. 26/34 in the control group, P = 0.398).
CONCLUSIONS
Intravenous injection of low dose ketamine was not effective for reducing POST.

Keyword

Complications; Intubation; Ketamine

MeSH Terms

Cholecystectomy, Laparoscopic
Humans
Incidence
Injections, Intravenous
Intubation
Ketamine
Pharyngitis
Prospective Studies
Ketamine