Anesth Pain Med.  2015 Oct;10(4):257-260. 10.17085/apm.2015.10.4.257.

Preventive effect of ketamine gargling for postoperative sore throat after endotracheal intubation

• Kang HY
• Seo DY
• Choi JH
• Park SW
• Kang WJ

• KMID: 2148009
• DOI: http://doi.org/10.17085/apm.2015.10.4.257

Abstract

BACKGROUND
Postoperative sore throat (POST) is a relatively common complication after endotracheal intubation, and various methods has been proposed to prevent it. In the present study, we assessed the effectiveness of ketamine gargling for reducing POST.
METHODS
This study was conducted in a prospective, randomized, placebo-controlled, and single-blinded manner. The study populations consisted of 40 patients between 20 and 60 years old who were classified as American Society of Anesthesiologists physical status I-II and were scheduled for elective laparoscopic cholecystectomy. Patients in group K received ketamine (1 ml, 50 mg) in normal saline (29 ml), and they gargled with the given solution for 30 s before induction. Patients in group C received normal saline (30 ml) and gargled it for 30 s before induction. All patients were interviewed 1, 6, and 24 h after the operation. The visual analog scale (VAS) score of POST was checked.
RESULTS
The VAS scores of POST were significantly lower in group K than in group C at 1 and 6 h after the operation. However, there were no significant differences in VAS scores at 24 h after the operation.
CONCLUSIONS
Preoperative ketamine gargling temporarily reduced POST in patients that underwent laparoscopic cholecystectomy.

Keyword

Gargle; Ketamine; Postoperative sore throat

MeSH Terms

Cholecystectomy, Laparoscopic
Humans
Intubation, Intratracheal*
Ketamine*
Pharyngitis*
Prospective Studies
Visual Analog Scale
Ketamine