Korean J Anesthesiol.  2011 Mar;60(3):161-166. 10.4097/kjae.2011.60.3.161.

The BIS and hemodynamic changes in major burn patients according to a slow infusion of propofol for induction

• Bae JY
• Choi DY
• Woo CH
• Kwak IS
• Mun SH
• Kim KM

• KMID: 2236465
• DOI: http://doi.org/10.4097/kjae.2011.60.3.161

Abstract

BACKGROUND
Many pathophysiologic alterations in patients with major burns can cause changes in the response of propofol. The aim of this study is to determine the appropriate induction dose of propofol using a slow infusion rate for major burn patients to obtain desirable sedation and hypnotic conditions with minimal hemodynamic changes.
METHODS
45 adults with major burns and who were electively scheduled for escharectomy less than a week after injury were recruited. For induction with propofol, the patients were randomly allocated to one of two groups (group 1: 1.5 mg/kg, n = 20 and group 2: 2.0 mg/kg, n = 25). The infusion rate was 20 mg/kg/hr. The systolic and diastolic blood pressure (SBP, DBP), the heart rate, the bispectral index and the modified observers' assessment of the alertness/sedation scale (OAA/S) were measured before the induction and after the propofol infusion, as well as immediately, 3 and 5 minutes after intubation.
RESULTS
The SBP and DBP were significantly decreased after the propofol infusion in both group, but there were no significant differences between the two groups. The BIS values after the propofol infusion and intubation were 44.2 +/- 16.1 and 43.5 +/- 13.8 in group 1, and 45.6 +/- 10.3 and 46.5 +/- 11.4 in group 2, respectively, and there were no differences between the 2 groups.
CONCLUSIONS
When propofol is administrated to major burn patients, an induction dose of 1.5 mg/kg is appropriate and a slow infusion rate of 20 mg/kg/hr is safe for maintaining the desired hypnotic conditions and this dose and rate cause no significant hemodynamic problems.

Keyword

Bispectral index monitors; Burns; Infusions; Intravenous; Propofol

MeSH Terms

Adult
Blood Pressure
Burns
Consciousness Monitors
Heart Rate
Hemodynamics
Humans
Intubation
Propofol
Propofol