Korean J Anesthesiol.  2013 Jan;64(1):12-18. 10.4097/kjae.2013.64.1.12.

Comparison of effects of fentanyl and remifentanil on hemodynamic response to endotracheal intubation and myoclonus in elderly patients with etomidate induction

• Ko BJ
• Oh JN
• Lee JH
• Choi SR
• Lee SC
• Chung CJ

• KMID: 2236228
• DOI: http://doi.org/10.4097/kjae.2013.64.1.12

Abstract

BACKGROUND
Etomidate has a stable hemodynamic profile after induction, but hypertension and tachycardia are frequent after intubation as well as myoclonus. We compared the effects of fentanyl and remifentanil on the hemodynamic response to intubation and myoclonus during etomidate induction in elderly patients.
METHODS
Ninety ASA I or II patients aged over 65 were randomly assigned to 3 groups. Group C received normal saline 10 ml (n = 30), group F and R were pretreated with fentanyl 1.0 microgram/kg (n = 30) or remifentanil 1.0 microgram/kg with continuous infusion of 0.1 microgram/kg/min (n = 30) 1 min before induction with etomidate 0.2 mg/kg. Endotracheal intubation was performed after administration of rocuronium 0.8 mg/kg. Systolic blood pressure (SBP), mean arterial pressure, diastolic blood pressure (DBP), heart rate (HR), and the incidence and intensity of myoclonus were recorded.
RESULTS
After intubation, group R showed significant decreases compared with groups C and F for all of the hemodynamic variables measured. The incidences of increases in SBP and HR of more than 30% of the baseline levels, SBP of > 200 mmHg, and HR of > 120 beats/min were significantly lower in group R (0%, 10%, 0%, and 0%, respectively) compared with groups C (83%, 83%, 30%, and 13%, respectively) and F (63%, 77%, 13%, and 7%, respectively). The frequency and intensity of myoclonus were significantly decreased in both groups F and R compared with group C.
CONCLUSIONS
Pretreatment with remifentanil suppressed cardiovascular reactions to endotracheal intubation more effectively than that of fentanyl during etomidate induction. Both opioids reduced the incidence of myoclonus.

Keyword

Endotracheal intubation; Etomidate; Fentanyl; Remifentanil

MeSH Terms

Aged
Analgesics, Opioid
Androstanols
Arterial Pressure
Blood Pressure
Etomidate
Fentanyl
Heart Rate
Hemodynamics
Humans
Hypertension
Incidence
Intubation
Intubation, Intratracheal
Myoclonus
Piperidines
Tachycardia
Analgesics, Opioid
Androstanols
Etomidate
Fentanyl
Piperidines