Korean J Fam Med.  2011 Sep;32(6):334-340. 10.4082/kjfm.2011.32.6.334.

Association of Heart Rate Variability with the Framingham Risk Score in Healthy Adults

• Yoo CS
• Lee K
• Yi SH
• Kim JS
• Kim HC

• KMID: 2235525
• DOI: http://doi.org/10.4082/kjfm.2011.32.6.334

Abstract

BACKGROUND
The aim of this study was to investigate the relationship between heart rate variability (HRV), the Framingham risk score (FRS), and the 10-year risk of coronary heart disease (CHD) development among Korean adults.
METHODS
The subjects were 85 healthy Korean adults recruited from a health check-up center. The FRS and 10-year risk of CHD development were calculated.
RESULTS
The FRS in men was inversely correlated with the standard deviation of all normal to normal RR-intervals (SDNN); the root mean square successive difference (RMSSD); the percentage of successive normal cardiac inter-beat intervals greater than 20 ms, 30 ms, and 50 ms (pNN20, pNN30, pNN50); the low frequency (LF); and the high frequency (HF) (P < 0.05). There was no significant relationship between the FRS and HRV in women. Overall, in the receiver operating characteristic (ROC) analysis, the RMSSD, HF, SDNN, LF, LF/HF ratio, and pNN30 predicted an increased 10-year CHD risk. After adjusting for sex and body mass index, those with greater than one standard deviation in the RMSSD, HF, and LF had a 52-59% reduction in their 10-year risk of CHD development > or = 10%.
CONCLUSION
This study therefore indicates that the HRV indices, particularly SDNN, RMSSD, pNN30, LF, and HF may be useful parameters for the assessment of CHD risk. Most notably, the usefulness of these HRV measures as indicators for CHD risk evaluation may be greater among men than among women.

Keyword

Heart Rate; Risk Assessment; Electrocardiography

MeSH Terms

Adult
Body Mass Index
Coronary Disease
Electrocardiography
Female
Heart
Heart Rate
Humans
Male
Risk Assessment
ROC Curve