Korean J Fam Med.  2009 Jun;30(6):457-463. 10.4082/kjfm.2009.30.6.457.

Relationship of Serum Homocysteine with Brachial-Ankle Pulse Wave Velocity in Middle Aged Women

• Park BJ
• Chun HY
• Han AR
• Lim JA
• Lee DC
• Shim JY
• Lee HR

• KMID: 2234569
• DOI: http://doi.org/10.4082/kjfm.2009.30.6.457

Abstract

BACKGROUND: Several studies showed the relationship between serum homocysteine and pulse wave velocity, but their subjects were confined to high risk group for cardiovascular diseases and recent study revealed no relationship in young healthy adults. We hypothesized that time interval would be needed for serum homocysteine to infl uence pulse wave velocity after exposure to vascular endothelium. The purpose of this study was to determine the relationship between serum homocysteine and pulse wave velocity in middle aged women on the basis of that hypothesis and necessity for further study in general population.
METHODS
The study subjects were 110 middle aged women who visited a health promotion center of a general hospital. We collected medical history by means of self-reported questionnaire and measured height, weight, blood pressure and brachial-ankle pulse wave velocity (baPWV). Blood sampling was performed after overnight fasting. We analyzed the relationship between several cardiovascular risk factors and baPWV and performed multiple regression analysis.
RESULTS
BaPWV velocity was correlated significantly with age, mean blood pressure, serum homocysteine, total cholesterol and diabetes mellitus, but not with body mass index, high-density lipoprotein cholesterol, triglyceride, creatinine clearance, alcohol intake, hypertension and smoking. In multiple regression, there was a significant association between age (P = 0.04), moderate hyperhomocysteinemia (P = 0.02), mean blood pressure (P < 0.001) and baPWV.
CONCLUSION
In middle aged women, there was an independently positive association between serum homocysteine and baPWV

Keyword

Homocysteine; Pulse Wave Velocity; Cardiovascular Diseases; Middle Aged Women

MeSH Terms

Adult
Blood Pressure
Body Mass Index
Cardiovascular Diseases
Cholesterol
Creatinine
Diabetes Mellitus
Endothelium, Vascular
Fasting
Female
Health Promotion
Homocysteine
Hospitals, General
Humans
Hyperhomocysteinemia
Hypertension
Lipoproteins
Middle Aged
Pulse Wave Analysis
Risk Factors
Smoke
Smoking
Cholesterol
Creatinine
Homocysteine
Lipoproteins
Smoke