Int Neurourol J.  2010 Dec;14(4):227-231.

Short Term Effect and Safety of Antidiuretic Hormone in the Patients with Nocturia

• Kang DI
• Kim HM
• Oh SY
• Yoon JH
• Kim HM
• Min KS

Abstract

PURPOSE
To investigate the short-term safety of antidiuretic hormone in elderly patients with nocturnal polyuria, focus on hyponatremia and others electrolytes disturbances and to assess short-term effects on nocturnal urine output and number of nocturnal voids.
METHODS
Between June 2005 and August 2006, a total of 34 patients with nocturnal polyuria were orally administered 0.2 mg desmopressin tablet at bedtime for two weeks. Serum sodium, others electrolytes, urine sodium and urine osmolarity were assessed in the third days, one week and two weeks after treatment with desmopressin and compared adult group (<65 years of age) with elderly group (> or =65 years of age). We assessed the effect of desmopressin using a frequency-volume charts and analysed.
RESULTS
In total 34 patients (20 adult, 14 elderly) were analyzed. Desmopressin treatment did not significantly change serum and urine electrolytes include soduim concentration in elderly patients comparied with adult patients. Serum sodium concentration below normal range was recorded in 2 patients in elderly group, but no serious adverse events occurred and recovered without sequelae. The mean number of nocturnal voids decresed (54% reduction) and nocturnal urine output decreased (57% reduction) after using desmopressin.
CONCLUSIONS
Desmopressin was well tolerated and effective in elderly patients with nocturnal polyuria without clinically significant hyponatremia.

Keyword

Desmopressin; Nocturia; Elderly; Hyponatremia

MeSH Terms

Adult
Aged
Deamino Arginine Vasopressin
Electrolytes
Humans
Hyponatremia
Nocturia
Osmolar Concentration
Polyuria
Reference Values
Sodium
Deamino Arginine Vasopressin
Electrolytes
Sodium