Int Neurourol J.  2010 Apr;14(1):1-6.

Experimental Animal Models of Neurogenic Bladder Dysfunction

• Yoo KH
• Lee SJ

Abstract

Neurogenic bladder is related to various types of neurogenic disease and injury, including cerebrovascular accident, brain tumor, spinal cord injury, and Parkinson's disease. The results of urodynamic study show different types of detrusor and sphincter function. According to these urodynamic results, the physician decides on a treatment plan, such as anticholinergics or alpha-blockers. In the development of a new medication, it is necessary to test the medication's efficacy and toxicity by using a laboratory animal. The proper laboratory animal should have several characteristics. These are biological similarity to humans, a short generation period, and an environment that is easy to control. We describe the development of laboratory animals for the study of neurogenic bladder by decerebration, stroke, and spinal cord injury.

Keyword

Laboratory animal; Neurogenic bladder; Procedure

MeSH Terms

Animals, Laboratory
Brain Neoplasms
Cholinergic Antagonists
Humans
Models, Animal
Parkinson Disease
Spinal Cord Injuries
Stroke
Urinary Bladder, Neurogenic
Urodynamics
Cholinergic Antagonists