Korean J Dermatol.  1987 Aug;25(4):446-450.

Effect of An Allergic Contact Dermatitis on the Irritant Response in Guinea Pigs

• Seong YK
• Eun HC

Abstract

The effect of an allergic contact dermatitis on the irritant was studied using DNCB(2. 5% in acetone) as the sensitizing agent and sodium lauryl sulfate of various concentrations (0. 5, 1. 0, 2. 0% in Vaseline) as the irritant. Three groups of 30 albino Hartley strain female guinea pigs weighing between 350 g and 500 g were used. The results were as follows: 1. The animals which were sensitized with DNCB were shown to be significantly(p<0.05) more irritable than control animals. 2. The animals which were sensitized and challenged with DNCB were shown to be significantly(p<0. 05) more irritable than control and sensitized animals. These data suggest that allergic contact sensitivity as well as allergic contact dermatitis lower the threshold to a nonspecific irritant in guinea pigs, which may explain a mechanism of 'angry back syndrome.

Keyword

Allergic contact dermatitis; Angry back syndrome; Guinea pig

MeSH Terms

Animals
Dermatitis, Allergic Contact*
Dermatitis, Contact
Dinitrochlorobenzene
Female
Guinea Pigs*
Guinea*
Humans
Sodium Dodecyl Sulfate
Dinitrochlorobenzene
Sodium Dodecyl Sulfate