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The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs

Hussain Z, Jung DH, Lee YJ, Park H

  • KMID: 2422856
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):669-675.
  • doi: 10.5056/jnm18049
BACKGROUND/AIMS: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing...
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Histological study on the effect of nicotine on adult male guinea pig thin skin

Eltony SA, Ali SS

Tobacco smoking has been identified as an important factor in premature skin aging to detect the histological changes occurred in adult male guinea pig thin skin under the influence of...
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The Effect of Peripheral CRF Peptide and Water Avoidance Stress on Colonic and Gastric Transit in Guinea Pigs

Hussain Z, Kim HW, Huh CW, Lee YJ, Park H

Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) diseases; however, there is frequent overlap between FD and IBS patients. Emerging evidence links the activation of corticotropin...
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Isolation, Characterization and Growth Kinetic Comparison of Bone Marrow and Adipose Tissue Mesenchymal Stem Cells of Guinea Pig

Aliborzi G, Vahdati A, Mehrabani , Hosseini S, Tamadon A

BACKGROUND: Mesenchymal stem cells (MSCs) from different sources have different characteristics. Moreover, MSCs are not isolated and characterized in Guinea pig for animal model of cell therapy. AIM OF THE WORK:...
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Measurement of the Mechanical Deformation of Organ of Corti in a Model of Acute Endolymphatic Hydrops

Lee SH, Kalinec F

BACKGROUND AND OBJECTIVES: Endolymphatic hydrops has been considered as an important histologic substrate of Meniere's disease. A permanent displacement of basilar membrane (BM) by increased endolymphatic pressure has been thought...
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The Effects of an Extract of Atractylodes Japonica Rhizome, SKI3246 on Gastrointestinal Motility in Guinea Pigs

Park JJ, Chon NR, Lee YJ, Park H

  • KMID: 2433474
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):352-360.
  • doi: 10.5056/jnm14112
BACKGROUND/AIMS: There are limited therapeutic options available for irritable bowel syndrome with diarrhea (IBS-D). We tested the effects of Atractylodes japonica rhizome, a perennial plant native to North Asia, on...
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Cholesterol-induced inflammation and macrophage accumulation in adipose tissue is reduced by a low carbohydrate diet in guinea pigs

Aguilar D, deOgburn R, Volek JS, Fernandez

BACKGROUND/OBJECTIVES: The main objective of this study was to evaluate the effects of a high cholesterol (HC) dietary challenge on cholesterol tissue accumulation, inflammation, adipocyte differentiation, and macrophage infiltration in...
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Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue

Lee TH, Seo JO, Do MH, Ji E, Baek SH, Kim SY

Synthetic compounds that are used in the clinic to regulate skin hyperpigmentation, such as arbutin, hydroquinone, and kojic acid, are only moderately effective. But, their use is limited by side...
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Effect of nicotine on the structure of cochlea of guinea pigs

Abdel-Hafez AMM, Elgayar SA, Husain OA, Thabet HS

Smoking has been positively associated with hearing loss in human. However, its effect on the cochlea has not been previously evaluated. Aim of work is to investigate the effect of...
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Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Lee TH, Seo JO, Baek SH, Kim SY

  • KMID: 2048328
  • Biomol Ther.
  • 2014 Jan;22(1):35-40.
Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits...
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Kinetics of IFN-Gamma and TNF-Alpha Gene Expression and Their Relationship with Disease Progression after Infection with Mycobacterium Tuberculosis in Guinea Pigs

Roh IS, Cho S, Eum SY, Cho SN

PURPOSE: Guinea pig is one of the most suitable animal models for Mycobacterium tuberculosis (M. tb) infection since it shows similarities to pulmonary infection in humans. Although guinea pig shows...
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Effect of coenzyme Q10 and Ardisia japonica Blume on plasma and liver lipids, platelet aggregation, and erythrocyte Na efflux channels in simvastatin-treated guinea pigs

Kang MS, Yang HM, Kang JY, Ryou SH, Kang JS

  • KMID: 2313623
  • Nutr Res Pract.
  • 2012 Oct;6(5):414-420.
Forty guinea pigs were divided into four groups and fed 0.04% cholesterol based control diet, plus 0.05% simvastatin, and statin plus 0.1% CoQ10 or 10% Ardisia Japonica Blume (AJB) leave...
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Serological Correlate of Protection in Guinea Pigs for a Recombinant Protective Antigen Anthrax Vaccine Produced from Bacillus brevis

Chun JH, Choi OJ, Cho MH, Hong KJ, Seong WK, Oh HB, Rhie GE

Objective Recombinant protective antigen (rPA) is the active pharmaceutical ingredient of a second generation anthrax vaccine undergoing clinical trials both in Korea and the USA. By using the rPA produced from...
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Binaural Electric-Acoustic Interactions Recorded from the Inferior Colliculus of Guinea Pigs: The Effect of Masking Observed in the Central Nucleus of the Inferior Colliculus

Noh H, Lee DH

OBJECTIVES: To investigate the electric-acoustic interactions within the inferior colliculus of guinea pigs and to observe how central masking appears in invasive neural recordings of the inferior colliculus (IC). METHODS: A...
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Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet

Kim JE, Clark RM, Park Y, Lee J, Fernandez

  • KMID: 2313582
  • Nutr Res Pract.
  • 2012 Apr;6(2):113-119.
Guinea pigs were fed a hypercholesterolemic diet (0.25 g/100 g cholesterol) and randomly allocated either to a Control group (n = 9) or to a Lutein (0.1 g/100 g) group...
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Skin Sensitization Study of Bee Venom (Apis mellifera L.) in Guinea Pigs

Han SM, Lee GG, Park KK

  • KMID: 2052544
  • Toxicol Res.
  • 2012 Mar;28(1):1-4.
Bee venom (Apis mellifera L., BV) has been used as a cosmetic ingredient for antiaging, anti-inflammatory and antibacterial functions. The aim of this study was to access the skin sensitization...
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Forskolin Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Ileum

Han KH, Cheon GJ, Yeon DS, Kwon SC

This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic Ca2+ level ([Ca2+]i), and Ca2+ sensitivity in guinea pig ileum. Forskolin (0.1 nM~10...
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Ca2+-activated K+ Current in Freshly Isolated c-Kit Positive Cells in Guinea-pig Stomach

Kim YC, Suzuki H, Xu WX, Choi W, Kim SH, Lee SJ

This study was designed to isolate Ca2+-activated K+ current (IKCa) and elucidate its physiological significance in freshly isolated interstitial cells of Cajal (ICCs) of guinea-pig stomach. Single ICC was freshly...
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Effect of Growth Factors on Hearing Restoration in Deafened Animal Model

Kim JH, Park SN, Yeo SW, Kim YH, Jin SY, Kim JH, Cho SJ, Kim JH, Choi MY, Park KH

  • KMID: 2276966
  • Korean J Otorhinolaryngol-Head Neck Surg.
  • 2008 Dec;51(12):1093-1098.
BACKGROUND AND OBJECTIVES: Sensorineural hearing loss is caused by ototoxic drugs, radiation therapy, noise exposure and trauma, etc. They make irreversible changes in cochlear hair cells and degeneration of spiral...
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Effect of Intrauterine Growth Restriction on Cell Proliferation in the Fetal Cerebellum of the Guinea Pig

Hyun YS, Chung YY, Rees S

  • KMID: 2283436
  • Korean J Phys Anthropol.
  • 2008 Sep;21(3):191-202.
Intrauterine growth restriction (IUGR) is a risk factor for neurological and behavioral deficits in children although the precise underlying biological mechanisms are unclear. It is also unclear whether IUGR affects...
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