Korean J Dermatol.  1992 Jun;30(3):362-367.

Phototoxic reaction to amidarone as studied with the mouse tail technique and the candida albicans test

• Kim BS
• Moon SE
• Kim JA
• Youn JI

Abstract

We carried out the mouse tail technique and the Candida albicans test for the study of the phototoxic reaction to amiodarone. The mouse tail technique is based on the inflammatory response of mouse tails after systemic administration of the drug and UVA irradiation and the Candida albicans test is based on growth inhibition of Candida albicana In the mouse tail technique, following the administration of amiodarone and UVA irradia tion for 5 consecutive days, there was a significant increase(14% ) in the relative water content as compared to other control groups. In the Candida albicans test, UVA irradiation after pretreatment with amiodarone resulted in a clear Candida-free zone around the disc. The results showed that amiodarone had a phototoxic potential and that both of the methods were a good screening test for demonstrat.ing the phototoxicity of a certain drug.

Keyword

Amiodarone; Phototoxicity; Mouse tail technique; Candida albicans test

MeSH Terms

Amiodarone
Animals
Candida albicans*
Candida*
Dermatitis, Phototoxic
Mass Screening
Mice*
Tail*
Water
Amiodarone
Water