Korean J Dermatol.  1994 Apr;32(2):337-341.

Therapeutic Efectivity of Intralesional Injection of 5 - Fluorouracil to Basal Cell Carcinomas

• Lee YJ
• Koo DW

Abstract

Basal cell carcinomas(BCCs) are usually treated with ablative proccdures, but a nonsurgical treatment would conserve tissue and obtain a better cosmetic out come as well as treat patients who refuse surgery or those who are not good surgical candidates. Because of inadequate drug penetration, low cure rates, high recurence rates, and adverse reactions, such as contact dermatitis, topical 5-fluorouracil(5-FU) is unsaitble to treat nodular BCCs. But, int,ralesional 5-FU has been reported to be effective for nodular BCCs. The efficacy and safety of intralesional injection of 5-FU have been evaluated for treatment of BCCs. The results revealed that intralesional injection of 5-FU seems to be effective in the treatment of various premalignant and malignant skin lesions as well as BCCs without side effects.

Keyword

Basal Cell Carcinorna; Intralesional Injection of 5-FU

MeSH Terms

Carcinoma, Basal Cell*
Dermatitis, Contact
Fluorouracil*
Humans
Injections, Intralesional*
Skin
Fluorouracil