Korean J Dermatol.  2000 Nov;38(11):1527-1530.

A Case of Milia-like Idiopathic Calcinosis Cutis and Periorbital Syringomas in Down Syndrome

Affiliations
  • 1Department of Dermatology, Maryknoll Hospital, Pusan, Korea.

Abstract

Down syndrome is associated with a large number of abnormal skin features including syringoma. Milia-like idiopathic calcinosis cutis is one of the rare dermatoses associated with Down syndrome. It has been reported in children with Down syndrome and clinically suggested as milia. The histological features show small nodular foci of calcium within the papillary dermis and transepidermal elimination of calcium deposits occasionally. We describe a 14-year-old female affected by Down syndrome, who had whitish papules on both the dorsal hands and feet and periorbital syringomas. Histopathological findings of the papule on the dorsal hand showed calcium deposits as amorphous, basophilic masses in the upper dermis and focal discharge of calcium by means of transepidermal elimination.

Keyword

Milia-like idiopathic calcinosis cutis; Periorbital syringoma; Down syndrome

MeSH Terms

Adolescent
Basophils
Calcinosis*
Calcium
Child
Dermis
Down Syndrome*
Female
Foot
Hand
Humans
Skin
Skin Diseases
Syringoma*
Calcium
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