Korean Circ J.  1984 Jun;14(1):165-169. 10.4070/kcj.1984.14.1.165.

Clinical Observation on Antihypertensive Effects of Tripamide(Normonal(R))

• Park CH
• Lee MM
• Seo J
• Lee YW

• KMID: 2229824
• DOI: http://doi.org/10.4070/kcj.1984.14.1.165

Abstract

The antihypertensive effects of tripamide was studied in 19 cases of essential hypertension. After 4 weeks treatment with daily dosage of Tripamide (Normonal(R)) 15mg, the dosage was adjusted to 30mg in 10 cases. Before and after treatment laboratory tests were performed in 11 cases. The obtained results were as follows: 1) After 4 weeks treatment with daily dosage of Tripamide 15mg, mean systolic and diastolic blood pressure was decreased by 25 mmHg (12.7%) and 9.7 mmHg (8.5%) respectively(p<0.01), and in 58% of the cases, good or fair control of blood pressure was resulted. 2) After final treatment, mean systolic and diastolic blood pressure was decreased by 29.7 mmHg(15.1%) and 15.0 mmHg(120.5%) respectively(p<0.005) and in 79% of the cases, good or fair control of blood pressure was resulted. 3) There was no significant changes in the values of sodium, potassium, BUN, creatinine, uric acid, cholesterol, SGOT, SGPT and calcium after treatment. 4) There was no significant side effect except one case of mild fatigue and tingling sense of extrmities which were subsided spontaneousely.

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Blood Pressure
Calcium
Cholesterol
Creatinine
Fatigue
Hypertension
Potassium
Sodium
Uric Acid
Alanine Transaminase
Aspartate Aminotransferases
Calcium
Cholesterol
Creatinine
Potassium
Sodium
Uric Acid