Korean Circ J.  1984 Jun;14(1):157-163. 10.4070/kcj.1984.14.1.157.

A Clinical Study of Hypotensive Effect of Tripamide(Normonal(R)) in Essential Hypertension

• Lee CS
• Yoon YG
• Cho JG
• Kang JC
• Park OK

• KMID: 2229823
• DOI: http://doi.org/10.4070/kcj.1984.14.1.157

Abstract

The hypotensive effect of tripamide(Normonal(R)) were evaluated in 31 cases of essential hypertension. Fifteen to thirty mg of tripamide per day were administered continuously for 8 weeks. The results were as follows; 1) The systolic blood pressure was significantly lowered from 175+/-15 mmHg(Mean+/-SD) before treatment to 144+/-17 mmHg after treatment(p<0.01), and the diastolic blood pressure was significantly lowered from 106+/-11 mmHg before treatment to 90+/-12 mmHg after treatment(p<0.01). 2) The systolic blood pressure was lowered 20 mmHg or more in 25 out of 31 cases(80.7%), and the diastolic blood pressure was decreased 10 mmHg or more in 25 out of 31 cases(80.7%) at the end of 8 weeks treatement. 3) There was no significantl differences in the level of SGOT, serum cholesterol, serum electrolytes(Na+, K+, Cl-), BUN, creatinine and urinc acid before and after treatment with tripamide. 4) In most cases the subjective symptoms disappeared or became easier after tripamide treatment. 5) Profound weakness was developed in 2 cases during tripamide administration.

MeSH Terms

Aspartate Aminotransferases
Blood Pressure
Cholesterol
Creatinine
Hypertension*
Aspartate Aminotransferases
Cholesterol
Creatinine