Korean Circ J.  1971 Dec;1(2):27-33. 10.4070/kcj.1971.1.2.27.

Clinical Observation on the Effect of Parenteral Reserpine

• Seo JD
• Song JS
• Lee YW
• Kim DJ
• Lee SH

• KMID: 2229703
• DOI: http://doi.org/10.4070/kcj.1971.1.2.27

Abstract

Parenteral reserpine was given intramuscularly to 32 hospitalized hypertensive patients: 10 hypertensive patients without renal insufficiency, 3 hypertensive patients with heart failure, 10 hypertensive patients of malignant phase or with uremia, and 9 hypertensive patients with cerebrovascular accident. Follwoings were the result. 1. In the majority of patients, the effective dose of reserpine was 2 to 3 mg. 2. Reserpine given intramuscularly lowered blood pressure in 2 to 4 hours, had its maximum effect in 3 to 6 hours and had a duration of 3 to more than 24 hours (average 9 hours). 3. When effective dose of reserpine was given, blood pressure was lowered significantly (more than 30mmHg in mean blood pressure) in 18 patients (81.7%) of 22 hypertensive patients without renal insufficiency, and in 4 patients (40%) of 10 hypertensive patients with renal insufficiency. 4. Major side effect was drowsiness which was more evident in the patients with renal insufficiency. 5. Reserpine administered parenterally is an effective and safe agent for the treatment of hypertensive emergencies on a short term basis especially in the patient without renal insufficiency.

MeSH Terms

Blood Pressure
Emergencies
Heart Failure
Humans
Renal Insufficiency
Reserpine*
Sleep Stages
Stroke
Uremia
Reserpine