Korean J Dermatol.  1981 Dec;19(6):983-987.

Therapeutic Effect fo Intra atrerial Reserpine in CRST Syndrome

• Park JW
• Son SJ
• Shin S

Abstract

The CRST syndrome, first reported by Winterbauer, represents a benign variant of scleroderma and consists of calcinosis(C), Raynauds phenomenon(R), sclerodactyly(S) and telangiectasia(T). The authors report a case of CRST syndrome confirmed by both clinical and histopathological findings. A 62-year-old female developed subcutaneous nodules on both elbow and knee joints, Raynauds phenomenon, sclerodactyly with acrosclerosis and scleroderrnatous changes on both hands and forearms and telangiectasia on the face, neck, and hands of 15 years duration, but she had no difficulty in swallowing. The authors treated a case of CRST syndrome with weekly intra-arterial administration of reserpine and were impressed not only by the marked loosening of the skin but also by the striking effect on the Raynauds phenornena; the latter disappeared within a few weeks of treatment.

MeSH Terms

CREST Syndrome*
Deglutition
Elbow
Female
Forearm
Hand
Humans
Knee Joint
Middle Aged
Neck
Reserpine*
Skin
Strikes, Employee
Telangiectasis
Reserpine