Korean Circ J.  1971 Dec;1(2):23-26. 10.4070/kcj.1971.1.2.23.

The Effect of Diphenylhydantoin on the Action of Ouabain

• Kang SK
• Park OK

• KMID: 2229702
• DOI: http://doi.org/10.4070/kcj.1971.1.2.23

Abstract

The effect of diphenylhydantoin on LD 50 of ouabain was investigated in frogs, using "one hour frog method". LD50 of ouabain in control group was 1.90 microg/10g. A dose of 100 microg/10g diphenylhydantion did not affect the systemic manifestations of the frogs, but increase the LD50 of ouabain to 2.60 microg/10g. The difference of LD50 of ouabain and potency ratio between control group and diphenylhydantoin-treated group was statistically significant.

MeSH Terms

Lethal Dose 50
Ouabain*
Phenytoin*
Ouabain
Phenytoin