Korean Circ J.  1990 Dec;20(4):731-740. 10.4070/kcj.1990.20.4.731.

Clinical Evaluation of Anthracycline Cardiomyopathy Using Echocardiography : An Analysis of 53 Cases

• Lee YA
• Chun IS
• Ahn HS
• Noh CI
• Choi CY
• Yun YS

• KMID: 2229351
• DOI: http://doi.org/10.4070/kcj.1990.20.4.731

Abstract

The authors reviewed both clinical records and echocardiographic data of 53 children who received Daunorubicin or Doxorubicin therapy due to malignant tumors. The left ventricular function of all the patients has been serially evaluated by echocardiography. There was a progressive decrease in myocardial contractility as evidenced by changes in several parameters of left ventricular function with increasing cumulative dose of the drug. The systolic time interval(PEP/LVET) showed a threshold phenomenon and did not begin to increase until a total dose of 450mg/m2 had been reached. Thus the clinical significance of serial changes in noninvasive test alone was uncertain. The results of present study strongly suggested that the dose limitation by combined clinical, noninvasive, invasive, and morphologic criterial offer an advantage over the empirical dose limitation of dose limitation by shortening fraction(SF) or systolic time interval(STI).

Keyword

Anthracycline; Cardiomyopathy; Echocardiography

MeSH Terms

Cardiomyopathies*
Child
Daunorubicin
Doxorubicin
Echocardiography*
Humans
Ventricular Function, Left
Daunorubicin
Doxorubicin