Korean Circ J.  1991 Dec;21(6):1159-1164. 10.4070/kcj.1991.21.6.1159.

Prosthetic Mitral Valve Thrombosis; Diagnosis and Thrombolytic Therapy with Urokinase

• Chung N
• Yoon JH
• Jang YS
• Park SH
• Kim BO
• Shim WH
• Cho SY
• Kim SS
• Lee WK

• KMID: 2228998
• DOI: http://doi.org/10.4070/kcj.1991.21.6.1159

Abstract

Six cases of bileaflet mechanical mitral valve thrombosis were serially assessed by Doppler echocardiography and cinefluoroscopy during thrombolytic therapy with urokinase. Two patients had dual mechanical valve replacement in the aortic and mitral positions simultaneously. Bileaflet thrombosis was diagnosed by 2-dimensional echocardiography in three cases, Doppler echocardiography and cinefluoroscopy in six cases. Thrombolytic therapy using urokinase was successful in five patients (3 cases : UK 1,000,000 unit x 3 hours for 2 days, 2 cases ; UK 1,000,000 unit/24 hours for 5 and 7 days respecitively, 1 case ; UK 1,000,000 unit/hr x 3 hours for 1 day). The other one patients had massive cerebral thromboembolism and subsequently died. These study demonstrated the usefulness of Doppler echocardiography and cinefluoroscopy in diagnosis and serial assessment of thrombolytic therapy in the patients with mechanical mitral valve thrombosis.

Keyword

Mechanical valve thrombosis; Thrombolysis; Doppler echocardiography

MeSH Terms

Diagnosis*
Echocardiography
Echocardiography, Doppler
Humans
Mitral Valve*
Thromboembolism
Thrombolytic Therapy*
Thrombosis*
Urokinase-Type Plasminogen Activator*
Urokinase-Type Plasminogen Activator