Korean J Crit Care Med.  1998 Nov;13(2):186-193.

Changes of Sodium, Potassium, Chloride and Bicarbonateion Concentrations in Apneic Rabbits

• Kim HJ
• Yum KW
• Kim YR

Abstract

BACKGOUND: During apnea, as in any other acid-base disturbance, ion exchanges between intra- and extracellular compartments are expected, but few studies have reported such findings. The purpose of this study was to observe serum sodium, potassium, chloride and bicarbonate concentrations during apnea until death.
METHODS
Seventeen New Zealand White Rabbits (weight 2.0~3.0 kg) were subjected to apneic oxygenation. Then we measured heart rate, blood pressure, intracranial pressure, arterial blood gas analyses and serum electrolytes (sodium, potassium, chloride and bicarbonate) concentrations during apnea until death.
RESULTS
Heart rate decreased because of sinus bradyarrythmia at 10 minutes after apnea and thereafter continued to increase. Blood pressure increased up to 30 minutes after apnea and thereafter continued to decrease. Intracranial pressure consistently increased during apnea. Serum bicarbonate and chloride ion concentrations showed reciprocal changes, but there was no significant correlation. Serum sodium and potassium concentrations increased up to 40 minutes and 30 minutes respectively, and thereafter decreased until death. All serum ion concentrations were within normal limits.
CONCLUSION
The serum sodium, potassium, chloride and bicarbonate concentrations were maintained within normal limits during apneic oxygenation until death.

Keyword

Acid-base equilibrium; bicabonate; respiratory acidosis; Ions; chloride; potassium; sodium

MeSH Terms

Acid-Base Equilibrium
Acidosis, Respiratory
Apnea
Blood Gas Analysis
Blood Pressure
Electrolytes
Heart Rate
Intracranial Pressure
Ions
Oxygen
Potassium*
Rabbits*
Sodium*
Electrolytes
Ions
Oxygen
Potassium
Sodium