Korean J Clin Neurophysiol.  2015 Jun;17(1):31-34. 10.14253/kjcn.2015.17.1.31.

A Case of Squamous Cell Lung Cancer Representing as Guillain-Barre Syndrome Associated with Monospecific Anti-GD1b IgG

Affiliations
  • 1Department of Neurology, Kangwon National University School of Medicine, Chuncheon, Korea. dr.kim94@gmail.com

Abstract

We report a case with squamous cell lung cancer with concomitant Guillain-Barre syndrome (GBS) as a paraneoplastic syndrome. A 67-year-old patient who was previously diagnosed as metastatic squamous cell lung cancer developed mild symmetrical weakness, paresthesia and sensory ataxia. Nerve conduction study showed sensorimotor polyneuropathy. Analysis of cerebrospinal fluid showed high tilter for monospecific anti-GD1b IgG antibody without onconeuronal antibodies. After treatment with intravenous immunoglobulin, the patient's symptoms improved.

Keyword

Guillain-Barre syndrome; Paraneoplastic syndrome; Anti-GD1b antibody

MeSH Terms

Aged
Antibodies
Ataxia
Cerebrospinal Fluid
Guillain-Barre Syndrome*
Humans
Immunoglobulin G*
Immunoglobulins
Lung Neoplasms*
Neural Conduction
Paraneoplastic Syndromes
Paresthesia
Polyneuropathies
Antibodies
Immunoglobulin G
Immunoglobulins

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