Korean J Clin Neurophysiol.  2015 Jun;17(1):17-23. 10.14253/kjcn.2015.17.1.17.

Sleep Disturbances in Patients with Parkinson's Disease according to Disease Severity

• Lee SY
• Cheon SM
• Kim JW

• KMID: 2225215
• DOI: http://doi.org/10.14253/kjcn.2015.17.1.17

Abstract

BACKGROUND
Sleep-related disturbances and sleep disorders are common in Parkinson's disease (PD) and have a great impact on daily life of PD patients. This study was done to find the sleep characteristics and sleep disturbing factors in PD patients according to disease severity through clinical interview and polysomnographic (PSG) study.
METHODS
Fifty patients with PD (22 males, age 60.6 +/- 6.4, Hoehn and Yahr (HY) stage 2.7 +/- 1.0) were recruited and thoroughly interviewed about their sleep. PSG was performed on the patients taking routine antiparkinsonian medications. Patients were grouped into mild and moderate/severe group according to HY stage, and the results were compared between each group.
RESULTS
Ninety-four percent of total patients had one or more sleep-related disturbances based on the interview or PSG. On interview, the moderate/severe group complained more insomnia and REM sleep behavior disorder (RBD) than mild group. In PSG findings, the moderate/severe group showed lower sleep efficiency, longer sleep latency, REM sleep latency, waking time after sleep onset, and higher prevalence of RBD.
CONCLUSIONS
In this study, most patients with PD had sleep disturbances. Clinical interview and PSG findings revealed deterioration of sleep quality along the disease severity. Our results suggest that sleep disturbances in PD patients are prevalent and warrant clinical attention, especially to the patients with advanced disease.

Keyword

Parkinson; Sleep; Polysomnography

MeSH Terms

Humans
Male
Parkinson Disease*
Polysomnography
Prevalence
REM Sleep Behavior Disorder
Sleep Wake Disorders
Sleep Initiation and Maintenance Disorders
Sleep, REM

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