Korean Circ J.  2010 Jul;40(7):314-320. 10.4070/kcj.2010.40.7.314.

Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in Korean

• Lim JH
• Kim YK
• Kim YS
• Na SH
• Rhee MY
• Lee MM

• KMID: 2225174
• DOI: http://doi.org/10.4070/kcj.2010.40.7.314

Abstract

BACKGROUND AND OBJECTIVES
Associations have been reported between the serum uric acid (SUA) level, metabolic syndrome (MS), and atherosclerosis. We have determined the relationship between the SUA level, MS, and arterial stiffness in Korean.
SUBJECTS AND METHODS
Cross-sectional data from 1,276 adults who underwent routine laboratory tests and pulse wave velocity (PWV) measurements during a health check-up were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, diabetes, renal disease, or systemic disease, or were under treatment which would affect SUA levels, or taking medications for hypertension or dyslipidemia.
RESULTS
After adjustment for age, smoking status, total cholesterol (TC), and creatinine, the odds ratios (ORs, 95% confidence interval) of gender-specific quartiles of SUA for MS were 1.0, 1.28 (0.66-2.47), 1.46 (0.76-2.82), and 2.21 (1.15-4.26) in females, and 1.0, 1.33 (0.82-2.17), 1.60 (0.96-2.66), and 2.03 (1.21-3.40) in males. However, after adjustment for waist circumference, there were no significant differences in the ORs among the SUA quartile groups in females and males (both, p=NS). The Pearson's correlation coefficients for the relationship between SUA levels and heart-femoral (hf) PWVs or brachial-ankle (ba) PWVs were not significant in females and males (r=0.054 and r=0.015, respectively, in females; r=-0.036 and r=-0.015, respectively, in males; all, p=NS).
CONCLUSION
An elevated SUA level is associated with abdominal obesity among the MS components, but the SUA level is not associated with PWV in females or males.

Keyword

Uric acid; Metabolic syndrome

MeSH Terms

Adult
Atherosclerosis
Cardiovascular Diseases
Cholesterol
Creatinine
Dyslipidemias
Electrolytes
Female
Humans
Hypertension
Male
Obesity, Abdominal
Odds Ratio
Pulse Wave Analysis
Smoke
Smoking
Uric Acid
Vascular Stiffness
Waist Circumference
Cholesterol
Creatinine
Electrolytes
Smoke
Uric Acid

Figure

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  Fig. 1 Serum uric acid levels according to the number of metabolic syndrome components and gender. Error bars indicate SDs.

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  Fig. 2 Prevalence of metabolic syndrome according to the serum uric acid quartile and gender. Error bars indicate 95% confidence intervals. MS: metabolic syndrome.

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  Fig. 3 Prevalence of high heart-femoral pulse wave velocity (hfPWV) according to the serum uric acid quartile and gender. Error bars indicate 95% confidence intervals.

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  Fig. 4 Prevalence of high brachial-ankle pulse wave velocity (baPWV) according to the serum uric acid quartile and gender. Error bars indicates 95% confidence intervals.

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