Korean Circ J.  2012 Aug;42(8):528-537. 10.4070/kcj.2012.42.8.528.

Clinical Characteristics of Acute Aortic Syndrome in Korean Patients: From the Korean Multi-Center Registry of Acute Aortic Syndrome

Affiliations
  • 1Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 2Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. cdhlyj@yuhs.ac
  • 3Cardiology Division, Seoul St. Mary's Hospital, The Catholic University College of Medicine, Seoul, Korea.
  • 4Cardiology Division, Kyungpook National University Hospital, Daegu, Korea.
  • 5Cardiology Division, Ajou University Medical Center, Suwon, Korea.
  • 6Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
  • 7Cardiology Division, National Health Insurance Coperation Ilsan Hospital, Goyang, Korea.
  • 8Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 9Department of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 10Cardiology Division, Wonju Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 11Cardiology Division, Chonnam National University Hospital, Gwangju, Korea.

Abstract

BACKGROUND AND OBJECTIVES
Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS.
SUBJECTS AND METHODS
Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail.
RESULTS
The mean patient age was 60.1+/-14.5 years; the male-to-female ratio was M : F=297 : 231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period.
CONCLUSION
By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.

Keyword

Aortic diseases; Dissection; Hematoma; Population characteristics

MeSH Terms

Aneurysm, Dissecting
Aortic Diseases
Back Pain
Follow-Up Studies
Hematoma
Humans
Hypertension
Medical Records
Population Characteristics
Prognosis
Pyridines
Retrospective Studies
Risk Factors
Thiazoles
Thorax
Ulcer
Pyridines
Thiazoles

Figure

  • Fig. 1 Event-free survival between type A and type B aortic dissection. AD: aortic dissection.

  • Fig. 2 Death-free survival between type A and type B aortic dissection. AD: aortic dissection.


Cited by  2 articles

Incidence and Mortality Rates of Thoracic Aortic Dissection in Korea – Inferred from the Nationwide Health Insurance Claims
Jun Ho Lee, Yongil Cho, Yang Hyun Cho, Hyunggoo Kang, Tae Ho Lim, Hyo Jun Jang, Sun Kyun Ro, Hyuck Kim
J Korean Med Sci. 2020;35(40):e360.    doi: 10.3346/jkms.2020.35.e360.

Usefulness of Cardiac Biomarkers in the Evaluation of Prognosis and Cardiac Involvement in Patients with Acute Aortic Syndrome
Jong Yoon Kim, Kye Hun Kim, Yi Rang Yim, Jae Yeong Cho, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
J Lipid Atheroscler. 2016;5(1):27-36.    doi: 10.12997/jla.2016.5.1.27.


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