J Rhinol.  2003 Nov;10(1, 2):49-52.

A Case of Rhino-Orbito-Cerebral Mucormycosis

• Lee KC
• Hong SJ
• Kim TH
• Kang IG

Abstract

Rhino-orbito-cerebral mucormycosis is a rare opportunistic invasive fungal infection, with rapid progression and high mortality. It is characterized by an aggressive necrotizing infection spreading from the nose to the paranasal sinuses, orbit, and the brain. This disease is often associated with diabetic ketoacidosis, leukemia, malnutrition, AIDS and immunocompromis ed patients. Typical initial symptoms of a patient with rhino-orbito-cerebral mucormycosis are facial pain and swelling, headache, fever, and blood-tinged rhinorrhea. Symptoms rapidly progressed to facial or orbital cellulitis, proptosis, and visual loss, facial nerve palsy. We report a case report of a 66-year-old woman with poorly controlled diabetes mellitus who developed mucormycosis which involved unilateral paranasal sinus, orbit, and selective cranial nerves.

Keyword

Mucormycosis; Nose; Orbit; Cranial nerves

MeSH Terms

Aged
Brain
Cranial Nerves
Diabetes Mellitus
Diabetic Ketoacidosis
Exophthalmos
Facial Nerve
Facial Pain
Female
Fever
Headache
Humans
Leukemia
Malnutrition
Mortality
Mucormycosis*
Nose
Orbit
Orbital Cellulitis
Paralysis
Paranasal Sinuses