J Rheum Dis.  2013 Feb;20(1):40-43. 10.4078/jrd.2013.20.1.40.

A Case of Q Fever that may Mimic Systemic Lupus Erythematosus

Affiliations
  • 1Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea. bahai@schmc.ac.kr

Abstract

Q fever is a zoonosis caused by a Coxiella burnetii. Q fever is clinically variable, presenting as asymptomatic infection, pneumonia, hepatitis and endocarditis. Treatment of acute Q fever with doxycycline is usually successful. Autoantibodies, such as anti-mitochondrial antibodies, smooth muscle antibodies (SMA), anti-cardiolipin and lupus anticoagulant, often rise in acute Q fever infection. Some cases may occasionally meet the criteria for autoimmune disease like systemic lupus erythematosus. We report a first case of Q fever that may mimic systemic lupus erythematosus in Korea.

Keyword

Systemic lupus erythematosus (SLE); Q fever; Coxiella burnetii

MeSH Terms

Antibodies
Asymptomatic Infections
Autoantibodies
Autoimmune Diseases
Coxiella burnetii
Doxycycline
Endocarditis
Hepatitis
Hydrazines
Korea
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic
Muscle, Smooth
Pneumonia
Q Fever
Antibodies
Autoantibodies
Doxycycline
Hydrazines
Lupus Coagulation Inhibitor

Figure

  • Figure 1. Chest CT shows bilateral pleural effusion (arrows).


Reference

References

1. Fournier PE, Marrie TJ, Raoult D. Diagnosis of Q fever. J Clin Microbiol. 1998; 36:1823–34.
Article
2. Thomas JM, Mandell GL, Douglas RG, Bennet JE. Coxiella burnetii. Principles and practice of infectious disease. 1990; 23:23–36.
3. Devine P, Doyle C, Lambkin G. Combined determination of Coxiella burnetii-specific immunoglobulin M (IgM) and IgA improves specificity in the diagnosis of acute Q fever. Clin Diagn Lab Immunol. 1997; 4:384–6.
Article
4. Walker DH. Rickettsiae and rickettsial infections: the cur-rent state of knowledge. Clin Infect Dis. 2007; 45(Suppl 1):S39–44.
Article
5. Harris RJ, Storm PA, Lloyd A, Arens M, Marmion BP. Longterm persistence of Coxiella burnetii in the host after primary Q fever. Epidemiol Infect. 2000; 124:543–9.
6. Raoult D, Levy PY, Harlé JR, Etienne J, Massip P, Goldstein F, et al. Chronic Q fever: diagnosis and followup. Ann N Y Acad Sci. 1990; 590:51–60.
Article
7. Spelman DW. Q fever: a study of 111 consecutive cases. Med J Aust. 1982; 1:547–8. 551, 553.
8. Berlin T, Zandman-Goddard G, Blank M, Matthias T, Pfeiffer S, Weis I, et al. Autoantibodies in non-autoimmune individuals during infections. Ann N Y Acad Sci. 2007; 1108; 584–93.
Article
9. Zandman-Goddard G, Shoenfeld Y. Infections and SLE. Autoimmunity. 2005; 38:473–85.
Article
10. Vardi M, Petersil N, Keysary A, Rzotkiewicz S, Laor A, Bitterman H. Immunological arousal during acute Q fever infection. Eur J Clin Microbiol Infect Dis. 2011; 30:1527–30.
Article
11. Ohguchi H, Hirabayashi Y, Kodera T, Ishii T, Munakata Y, Sasaki T. Q fever with clinical features resembling systemic lupus erythematosus. Intern Med. 2006; 45:323–6.
Article
12. Bernit E, Pouget J, Janbon F, Dutronc H, Martinez P, Brouqui P, et al. Neurological involvement in acute Q fever: a report of 29 cases and review of the literature. Arch Intern Med. 2002; 162:693–700.
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