J Rheum Dis.  2015 Jun;22(3):175-179. 10.4078/jrd.2015.22.3.175.

A Case of Sweet's Syndrome Diagnosed Concomitantly with Sjogren's Syndrome

• Jang CM
• Kim SK
• Kim NH
• Lee SY
• Yoo KM
• Lee TH
• Chae HB
• Han KJ
• Joo EJ
• Ahn JK

• KMID: 2222883
• DOI: http://doi.org/10.4078/jrd.2015.22.3.175

Abstract

Sweet's syndrome is an uncommon reactive dermatoses characterized by fever, polymorphonuclear leukocytosis, painful erythematous plaques, and dense dermal infiltrate of neutrophils. Sweet's syndrome can be associated with several diseases, including infectious diseases, malignant tumors, and autoimmune diseases. However, no case of Sweet's syndrome associated with Sjogren's syndrome (SjS) has been reported in Korea. A 44-year-old woman presented with acute pustular rashes and fever. The patient had multiple papulopustular skin rashes, and complained of fever, chills, and headache. Our patient had the characteristic clinical and histopathological features of Sweet's syndrome, in association with SjS, diagnosed by salivary gland scan, positive anti-SS-A/SS-B antibody, and sicca symptoms simultaneously. Thus, we report on a case of a patient with Sweet's syndrome with concomitant diagnosis of SjS.

Keyword

Sweet syndrome; Sjogren's syndrome

MeSH Terms

Adult
Autoimmune Diseases
Chills
Communicable Diseases
Diagnosis
Exanthema
Female
Fever
Headache
Humans
Korea
Leukocytosis
Neutrophils
Salivary Glands
Sjogren's Syndrome*
Skin Diseases
Sweet Syndrome*

Figure

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  Figure 1. Erythematous papulopustular rash over face (A), neck (B), left forearm (C), and right auricle (D).

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  Figure 2. (A) Diffuse swelling and perimuscular inflammatory infiltration of the left psoas muscle. (B) After treatment of Sweet's syndrome, significant remission of swelling and perimuscular inflammatory infiltration has occurred.

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  Figure 3. The salivary gland scan shows decreased uptake and delayed washout of the radiotracer by both parotid glands and both submandibular glands. This finding suggests primary Sjögren's syndrome. ANT: anterior view, LAT: lateral view, LT: left, RT: right, PG: parotid gland, EF: ejection fraction, SMG: submandibular gland.

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  Figure 4. (A) The epidermis desquamated and diffuse infiltration of inflammatory cells in deep dermis (H&E, ×40). (B) An infiltration of predominantly neutrophils, without evidence of vasculitis (H&E, ×400).

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