J Korean Diabetes Assoc.  2007 Jul;31(4):372-376. 10.4093/jkda.2007.31.4.372.

Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus

• Cho HY
• Cho YM
• Park MH
• Kang MY
• Kim KH
• Ku YH
• Lee EK
• Park DJ
• Shin CS
• Park KS
• Kim SY
• Cho BY
• Lee HK

• KMID: 2222526
• DOI: http://doi.org/10.4093/jkda.2007.31.4.372

Abstract

Autoantibody negative fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and a negative islet-related autoantibodies. The prevalence of fulminant type 1 diabetes has large difference between Japan and other countries. The precise reason for this regional variation remains to be clarified. One of the possible explanations is genetic background such as genotype of class II HLA molecule. In addition, environment factors including viral infection are suggested as possible pathogenesis of the disease. Only a few cases with fulminant type 1 diabetes have been reported outside Japan, and most of these cases with definite diagnosis have been reported in Korea. We report here on two Korean patients that met the criteria for diagnosis of fulminant type 1 diabetes in accordance with their HLA genotypes.

Keyword

Fulminant; Human leukocyte antigen; Type 1 diabetes mellitus

MeSH Terms

Autoantibodies
Diabetes Mellitus, Type 1*
Diabetic Ketoacidosis
Diagnosis
Genotype
Humans
Japan
Korea
Prevalence
Autoantibodies

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