Ann Dermatol.  2009 May;21(2):209-212. 10.5021/ad.2009.21.2.209.

A Case of Epstein-Barr Virus-associated Hydroa Vacciniforme

• Huh SY
• Choi M
• Cho KH

• KMID: 2219400
• DOI: http://doi.org/10.5021/ad.2009.21.2.209

Abstract

Hydroa vacciniforme (HV) is a photosensitivity disorder characterized by recurrent necrotic vesiculopapules on sun-exposed areas, which heal spontaneously during adolescence. Recently, an association has been reported between latent Epstein-Barr virus (EBV) infection and atypical HV-like eruption and malignant potential. However, latent EBV infection has also been reported in the setting of typical HV. An 11-year-old girl presented with recurrent, scattered, discrete vesicular eruptions with scarring on the face and the extensor surfaces of both forearms. In-situ hybridization was carried out to detect latent EBV infection. Based on the clinical and histopathological findings, typical EBV-associated HV was suspected.

Keyword

Epstein-Barr virus; Hydroa vacciniforme

MeSH Terms

Adolescent
Child
Chimera
Cicatrix
Epstein-Barr Virus Infections
Forearm
Herpesvirus 4, Human
Humans
Hydroa Vacciniforme
Photosensitivity Disorders

Figure

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  Fig. 1 The patient showed multiple, discrete vesicular eruptions with scarring on the face (A) and the extensor surfaces of the forearms (B).

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  Fig. 2 (A) A skin biopsy obtained from the vesicular lesion on her forearm. Intraepidermal vesiculation with superficial and deep perivascular and periappendageal infiltrations in the upper dermis (H&E, ×200). (B) In situ hybridization. Many cells positive for EBV-encoded small nuclear RNA are present in the infiltrates (×200).

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  Fig. 3 Immunohistochemical stains. The dermal infiltrates are composed mainly of lymphocytes expressing CD3-positive (A) and CD45RO-positive (B) cells (Immunoperoxidase stain, ×100).

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