Ann Dermatol.  2009 May;21(2):193-196. 10.5021/ad.2009.21.2.193.

A Case of Leukemia Cutis at the Site of a Prior Catheter Insertion

• Lee JI
• Park HJ
• Oh ST
• Lee JY
• Cho BK

• KMID: 2219395
• DOI: http://doi.org/10.5021/ad.2009.21.2.193

Abstract

Leukemia cutis is the cutaneous involvement of leukemic neoplastic cells. It is an uncommon feature of systemic leukemia, and is associated with a poor prognosis. A 20-year-old man presented with a solitary, 2 cm dome- shaped, firm, erythematous nodule on the right medial malleolus that was present for 3 months. The patient had a history of venous catheter insertion at the right medial malleolus area 3 months previously. The history was significant for acute lymphoblastic leukemia (ALL) for 4 years; an allogenic bone marrow transplantation was performed 3 years earlier. The histologc examination of the lesion revealed diffuse infiltration of leukemic cells in the dermis and subcutis. Herein we report a case of leukemia cutis at the site of a prior catheter insertion in a patient with ALL

Keyword

Acute lymphocytic leukemia; Leukemia cutis; Site of catheter insertion

MeSH Terms

Bone Marrow Transplantation
Catheters
Dermis
Humans
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Young Adult

Figure

• 

  Fig. 1 Asymptomtic, solitary, domeshaped, firm, erythematous nodule on the right medial malleolus area.

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  Fig. 2 (A) The skin biopsy specimen of the nodule showed diffuse infiltration in the dermis and subcutis (H&E, ×40). (B) The infiltrated cells were small, polymorphic, atypical cells having hyperchromatic nuclei (H&E, ×400).

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  Fig. 3 Immunohistochemical features. The infiltrated cells were positive for (A) TdT (×200) and (B) CD79a (×200), and negative for (C) CD3 (×200) and (D) CD20 (×200).

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