J Korean Ophthalmol Soc.  2014 Oct;55(10):1476-1480. 10.3341/jkos.2014.55.10.1476.

Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

• Park SJ
• Moon YS
• Kim NR

• KMID: 2216865
• DOI: http://doi.org/10.3341/jkos.2014.55.10.1476

Abstract

PURPOSE
To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA).
METHODS
The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects.
RESULTS
The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber layer (RNFL) thickness. The GCIPL thickness tended to be thinner especially in the superior sector GCIPL. The GCIPL thickness of normal subjects, diabetes patients without diabetic retinopathy, and diabetic retinopathy patients was 82.24 +/- 7.21 microm, 81.86 +/- 9.53 microm, and 76.77 +/- 14.13 microm, respectively, especially in the superior sector GCIPL (p = 0.029).
CONCLUSIONS
Retinal ganglion cell layer thinning was induced by diabetes and diabetic retinopathy, and originated specifically from the superior part of the retina.

Keyword

Diabetes mellitus (DM); Ganglion cell-inner plexiform layer (GCIPL); Optical coherence tomography (OCT); Retinal nerve fiber layer (RNFL)

MeSH Terms

Diabetes Mellitus
Diabetic Retinopathy
Ganglion Cysts
Humans
Nerve Fibers
Retina
Retinal Ganglion Cells
Retinaldehyde
Tomography, Optical Coherence
Retinaldehyde

Figure

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  Figure 1. Peripapillary retinal nerve fiber layer (RNFL) thickness of diabetic patients groups and control group. The illustration shows that the RNFL layer thickness had no difference among the 3 groups. DM = diabtes mellitus; DMR = diabetic retinopathy.

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  Figure 2. Ganglion cell-inner plexiform layer (GCIPL) thickness of diabetic patients groups and control group. The illustration shows that the GCIPL thickness had tendency to be thinner in diabetic patients than norm al patients and in diabetic retinopathy than non-diabetic retinopathy diabetes mellitus patients. DM = diabtes mellitus; DMR = diabetic retinopathy.

Reference

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