J Korean Ophthalmol Soc.  2013 Feb;54(2):346-350. 10.3341/jkos.2013.54.2.346.

A Case of Rosai-Dorfman Disease Affecting the Palpebral Conjunctiva

• Lee JY
• Shin HM
• Lew H

• KMID: 2216673
• DOI: http://doi.org/10.3341/jkos.2013.54.2.346

Abstract

PURPOSE
To report a single case of Rosai-Dorfman disease of the palpebral conjunctiva with a review of the relevant literature.
CASE SUMMARY
A 39-years-old woman presented with a palpebral conjunctival mass 3 weeks in duration on both eyes. The patient had a history of excisional biopsy of lymphadenitis and wanted to remove the mass for cosmetic reasons. An excisional biopsy was performed to obtain a diagnosis for proper management. The histopathologic examination of the lesion showed an intensive proliferation of monotonous and histiocytoid cells beneath the epidermis. Immunohistochemical staining for the S-100 protein was positive and anti-CD1A antibody was negative. Five months after mass excision, there was no evidence of recurrence.

Keyword

Conjunctival mass; Palpebral conjunctiva; Rosai-Dorfman disease

MeSH Terms

Biopsy
Conjunctiva
Cosmetics
Epidermis
Eye
Female
Histiocytosis, Sinus
Humans
Lymphadenitis
Recurrence
S100 Proteins
Cosmetics
S100 Proteins

Figure

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  Figure 1. The photograph of the patient's eye before excisional biopsy. Hyperemic and smooth surfaced 25 × 10 mm sized mass was noted at the palpebral conjunctiva of right lower lid.

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  Figure 2. Computed tomographic findings. About 2.8-cm enlarged lymph node (arrow) at the right lateral retropharyngeal space. (A) Small enhancing solid nodule (arrow) at the left nasal cavity (B).

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  Figure 3. Medium power image demonstrating sinus histiocytosis (arrow) with massive lymphadenopathy (H&E, original magnification ×200).

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  Figure 4. M edium power image demonstrating scattered strongly S-100 positive histiocytes within the inflammatory infiltration (S-100, original magnification ×200).

Reference

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