J Korean Ophthalmol Soc.  2012 Sep;53(9):1231-1235. 10.3341/jkos.2012.53.9.1231.

The Effect of Mitomycin C Instillation after Silicone Intubation in Adult Partial Nasolacrimal Duct Obstruction

• Jeong JG
• Ahn M

• KMID: 2216074
• DOI: http://doi.org/10.3341/jkos.2012.53.9.1231

Abstract

PURPOSE
To compare the result of mitomycin C (MMC) instillation after silicone intubation in partial nasolacrimal duct obstruction in adults according to duration of instillation.
METHODS
An instillation of 0.04% MMC eyedrops was performed on 61 eyes of 38 patients diagnosed with partial nasolacrimal duct obstruction. The clinical result of patient groups, classified according to duration of MMC eyedrops instillation, was analyzed prospectively. The patients groups was as follows: no MMC eyedrop instillation (group A), 1 week of MMC instillation (group B), 2 weeks of MMC instillation (group C), and 3 weeks of MMC instillation (group D).
RESULTS
Among all patients, 50 eyes (81.9%) showed improved symptoms. Fifteen eyes (71.4%) in group A, 8 eyes (72.7%) in group B, 13 eyes (86.7%) in group C and 14 eyes (100.0%) in group D had a successful outcome. The success rate was observed in groups D, C, B, and A, in descending order, which was statistically significant (p = 0.025).
CONCLUSIONS
Silicone intubation is an effective treatment option for partial nasolacrimal duct obstruction in adults and MMC eyedrop instillation may improve silicone intubation results.

Keyword

Mitomycin-C; Nasolacrimal duct obstruction; Silicone intubation

MeSH Terms

Adult
Eye
Humans
Intubation
Mitomycin
Nasolacrimal Duct
Ophthalmic Solutions
Prospective Studies
Silicones
Mitomycin
Ophthalmic Solutions
Silicones

Figure

• 

  Figure 1 Clinical outcome of silicone intubation in partial nasolacrimal duct obstruction. Higher success rate in patients who used MMC instillation after silicone intubation (p < 0.001, Fisher's exact test). MMC = mitomycin C.

• 

  Figure 2 Clinical outcome of silicone intubation according to duration of MMC instillation. The success rate increases as the duration of MMC instillation increases (p = 0.025, linear by linear association). MMC = mitomycin C.

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