J Korean Ophthalmol Soc.  2012 Aug;53(8):1104-1111. 10.3341/jkos.2012.53.8.1104.

ON and OFF Responses of the Electroretinogram in Patients with Glaucoma

• Park KH
• Chang JH
• Park TK
• Ohn YH

• KMID: 2215952
• DOI: http://doi.org/10.3341/jkos.2012.53.8.1104

Abstract

PURPOSE
To investigate whether there is a difference in ON- and OFF-responses of the photopic electroretinogram (ERG) in glaucomatous eyes.
METHODS
Photopic ERG and optical coherence tomography were performed in 15 normal, 13 glaucoma suspect, and 22 glaucoma subjects. Amplitudes and implicit times for a, b, d, i, photopic negative response (PhNR), and retinal nerve fiber layer thickness were compared among the three groups.
RESULTS
The PhNROFF amplitude (microV) was 19.05 +/- 11.41 in the glaucoma group, 14.24 +/- 10.37 in the glaucoma suspect group, and 2.69 +/- 12.16 in the normal group, demonstrating a significant difference among the three groups (p < 0.01). The PhNRON amplitude (microV) was 20.15 +/- 13.99 in the glaucoma group, 31.49 +/- 17.09 in the glaucoma suspect group, and 37.59 +/- 9.53 in the normal group, a significant difference (p < 0.01). However, there was no significant difference between the three groups. The ON-OFF response PhNR amplitude was correlated with retinal nerve fiber thickness (r = 0.481, r = -0.480, respectively), and areas under the receiver operating characteristic curve were 0.782, and 0.718, respectively.
CONCLUSIONS
There is a potential role for the ON-OFF response PhNR in early detection of glaucomatous damage.

Keyword

Electroretinogram; Glaucoma; ON-OFF response; Photopic negative response

MeSH Terms

Glaucoma
Humans
Nerve Fibers
Retinaldehyde
ROC Curve
Tomography, Optical Coherence
Retinaldehyde

Figure

• 

  Figure 1 ON-OFF response electroretinogram show group-averaged responses from 15 normal subjects and 22 glaucoma patients. Photopic negative response of ON-response (PhNRON) is measured from the onset-level. Photopic negative response of OFF-response (PhNROFF) is measured from the offset level. Glaucoma patients show different amplitudes for the PhNRON, the PhNROFF in comparison with the normal eye.

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  Figure 2 Comparison of Photopic negative response (PhNR) amplitude in the ON-response and OFF-response among the three groups. *p < 0.05 by ANOVA and Scheffe test was considered to be significant.

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  Figure 3 Correlation of the photopic negative response (PhNR) amplitude in the ON-OFF response and the retinal nerve fiber layer thickness among the three groups. *p < 0.05 by Pearson correlation test was considered to be significant. (A) PhNRON response. (B) PhNROFF response.

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  Figure 4 The receiver operating characteristic (ROC) curve of photopic negative response (PhNR) amplitude of ON-response and PhNR amplitude of OFF-response for discrimination of glaucoma from normal eyes.

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