J Korean Ophthalmol Soc.  2011 Dec;52(12):1414-1418. 10.3341/jkos.2011.52.12.1414.

Preemptive Analgesic Effect of Topical NSAIDS in Postoperative Pain Relief after LASEK

• Kim SK
• Hong JP
• Nam SM
• Seo KY

• KMID: 2215143
• DOI: http://doi.org/10.3341/jkos.2011.52.12.1414

Abstract

PURPOSE
To assess the preemptive analgesic effect of topical NSAIDs (0.5% ketorolac tromethamine, Acular) as postoperative pain relief in patients undergoing LASEK.
METHODS
A prospective, randomized, placebo-controlled, paired eye study was performed. Patients undergoing LASEK were randomized to receive 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at 30 minutes, 20 minutes, or ten minutes prior to LASEK. Pain was assessed using a visual analog scale of 0 to 10 in each eye 6, 12, 24, 36, 48 and 72 hours after surgery. Patients were also asked to assess the levels of glare, tearing and irritation using a visual analog scale from 0 to 10.
RESULTS
A total of 62 eyes from 31 patients were enrolled in the present study. The mean postoperative pain score in the NSAID group was significantly lower than that in the placebo group at postoperative hours 6 (2.35 versus 4.97), 12 (2.52 versus 5.16), and 24 (3.84 versus 4.94) (p < 0.05). The mean postoperative pain score after 36 and 48hours was also lower in the NSAID group than in the placebo group, but the differences were not statistically significant (p > 0.05). Patients reported significantly less tearing and irritation in the NSAID-administered eye compared to those in the placebo eye after LASEK (p < 0.05).
CONCLUSIONS
Preemptive administration of topical NSAIDs before LASEK was effective in reducing acute postoperative pain. Preemptive analgesia with topical NSAIDs may be a valuable treatment option for controlling postoperative pain following ocular surgery.

Keyword

LASEK; Nonsteroidal anti-inflammatory drug; Pain; Preemptive analgesia

MeSH Terms

Analgesia
Anti-Inflammatory Agents, Non-Steroidal
Eye
Glare
Humans
Keratectomy, Subepithelial, Laser-Assisted
Ketorolac
Ketorolac Tromethamine
Ofloxacin
Pain, Postoperative
Prospective Studies
Anti-Inflammatory Agents, Non-Steroidal
Ketorolac
Ketorolac Tromethamine
Ofloxacin

Figure

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  Figure 1. Pain score change on each postoperative hour. VAS = visual analog scale; NSAID = non steroidal anti-inflammatory drug. ∗p < 0.05.

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