J Korean Ophthalmol Soc.  2011 Mar;52(3):355-358. 10.3341/jkos.2011.52.3.355.

A Case of Muir-Torre Syndrome

• Bae K
• Kim YD
• Woo KI

• KMID: 2214302
• DOI: http://doi.org/10.3341/jkos.2011.52.3.355

Abstract

PURPOSE
To present a rare case of Muir-Torre syndrome characterized by the association of sebaceous skin tumors and systemic malignancies.
CASE SUMMARY
A 65-year-old female visited our clinic with an irregular nodular mass of the right lower eyelid, which developed 1 year earlier. An excisional biopsy and lower lid reconstruction with Tenzel's semicircular rotational flap was performed under local anesthesia. Histopathologic examination showed well-differentiated sebaceous cells, consistent with sebaceous adenoma. The patient had undergone total abdominal hysterectomy and lower anterior resection due to endometrial cancer and sigmoid colon cancer 5 years before, and nephroureterectomy due to papillary urothelial carcinoma 3 years before. Based on the history of systemic malignancy and sebaceous skin cancer, a diagnosis of Muir-Torre syndrome was made.
CONCLUSIONS
When a sebaceous gland tumor of the eyelids is detected, Muir-Torre syndrome should be included in the differential diagnosis, and systemic work-up for the internal malignancy must be performed.

Keyword

Eyelid tumor; Muir-Torre syndrome; Sebaceous; Systemic malignancy

MeSH Terms

Adenoma
Aged
Anesthesia, Local
Biopsy
Diagnosis, Differential
Endometrial Neoplasms
Eyelids
Female
Humans
Hysterectomy
Muir-Torre Syndrome
Sebaceous Glands
Sigmoid Neoplasms
Skin
Skin Neoplasms

Figure

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  Figure 1. Clinical photograph showing an irregular nodular mass in the lower tarsal conjunctiva of the right eye.

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  Figure 2. Sebaceous gland adenoma. Microscopically the tumor exhibited a lobular pattern with basaloid cells at the periphery of the lobules with central areas of sebaceous differentiation (hematoxylin and eosin, original magnification ×100 (A), ×400 (B)).

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  Figure 3. The patient's photograph taken 18 months after surgery shows no recurrence.

Reference

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