J Korean Ophthalmol Soc.  2016 Mar;57(3):445-452. 10.3341/jkos.2016.57.3.445.

Clinical Outcomes of Indocyanine Green-Assisted Peeling of the Internal Limiting Membrane in Epiretinal Membrane Surgery

• Choi WS
• Jeong WJ
• Kwon YH

• KMID: 2213246
• DOI: http://doi.org/10.3341/jkos.2016.57.3.445

Abstract

PURPOSE
In this study we compared the clinical outcomes of idiopathic epiretinal membrane (ERM) surgery according to the use of indocyanine green (ICG) and ICG exposure time.
METHODS
The medical records of 76 patients with an idiopathic ERM that underwent vitrectomy and ERM and internal limiting membrane (ILM) removal were reviewed. We compared the results (best corrected visual acuity [BCVA, log MAR] and central macular thickness [CMT, µm]) of idiopathic ERM surgeries using ILM peeling with (group I, 39 eyes) and without ICG (group II, 37 eyes). Additionally, the correlation of ICG exposure time and clinical outcomes in group I was analyzed.
RESULTS
Gender, age, lens state, preoperative BCVA, and preoperative CMT were not significantly different between the two groups. The postoperative BCVA was significantly improved in both groups but the difference was not statistically significant. The postoperative CMT was significantly improved in both groups and the change amount of group I was more larger than group II. Additionally, ICG exposure time was not significantly correlated with changes of BCVA and CMT.
CONCLUSIONS
Intravitreal ICG-assisted ILM peeling did not significantly affect the recovery of BCVA, however that impaired the recovery of CMT. ICG exposure time did not affect the postoperative visual outcome.

Keyword

Exposure time; Idiopathic epiretinal membrane; Indocyanine green; Internal limiting membrane

MeSH Terms

Epiretinal Membrane*
Humans
Indocyanine Green
Medical Records
Membranes*
Visual Acuity
Vitrectomy
Indocyanine Green

Figure

• 

  Figure 1. Comparison of the change amount of BCVA (log MAR) and the CMT (μm) in the two groups. (A) The change amount of BCVA (log MAR) did not differ significantly between the two groups at any point. (B) The change amount of CMT (μm) in the ‘ICG dye with triamcinolone’ group was significantly smaller than that in the ‘triamcinolone only’ group at 3 months after surgery (p = 0.042, *Student t-test). BCVA = best corrected visual acuity; CMT = central macular thickness; Post op. = postoperative; ICG = indocyanine green.

• 

  Figure 2. Scatter plots of ICG exposure time versus BCVA change and CMT change of 3 months value after operation. (A) ICG exposure time is not significantly correlated with BCVA change (r* = −0.55, p = 0.74). (B) ICG exposure time is not significantly correlated with CMT change (r* = −0.312, p = 0.71). ICG = indocyanine green; BCVA = best corrected visual acuity; CMT = central macular thickness. *Pearson's correlation test.

Reference

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