J Korean Ophthalmol Soc.  2010 Feb;51(2):241-247. 10.3341/jkos.2010.51.2.241.

Analysis of Systemic Factors through Blood Examination in Normal-Tension Glaucoma Patients

• Lee NY
• Ahn MD

• KMID: 2213146
• DOI: http://doi.org/10.3341/jkos.2010.51.2.241

Abstract

PURPOSE
In this study, we evaluated systemic hemodynamic factors of normal tension glaucoma.
METHODS
Forty patients with normal tension glaucoma and thirty healthy people were investigated with regard to hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, triglycerides, LDL, HDL, and high-sensitivity C-reactive protein (hsCRP). Also, ET-1 and MCP-1 were measured using enzyme-linked immunosorbent assay kits.
RESULTS
The results of the blood examinations showed no statistically significant differences in hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, LDL, HDL, and hsCRP. Only triglycerides showed a statistically significant difference between the groups (P=0.03). The level of serum ET-1 was significantly higher in the normal tension glaucoma group (P=0.007). The results of MCP-1 showed no statistically significant difference.
CONCLUSIONS
We conclude that normal tension glaucoma Is associated with an increased level of triglycerides and that the level of ET-1 could be a hemodynamic cause of normal tension glaucoma.

Keyword

Endothelin-1; Hemodynamic factors; High-sensitivity C-reactive protein; Macrophage chemoattractant protein-1; Normal tension glaucoma

MeSH Terms

C-Reactive Protein
Cholesterol
Cholesterol, LDL
Endothelin-1
Enzyme-Linked Immunosorbent Assay
Fasting
Glaucoma
Glucose
Hematocrit
Hemodynamics
Hemoglobins
Humans
Low Tension Glaucoma
Platelet Count
Triglycerides
C-Reactive Protein
Cholesterol
Cholesterol, LDL
Endothelin-1
Glucose
Hemoglobins
Triglycerides

Figure

• 

  Figure 1. Graphs demonstrating the value of total cholesterol, triglyceride, LDL, HDL and high-sensitivity C-reactive protein (hs CRP) in the control group and the normal-tension glaucoma (NTG) group. Each dot represents the average of each factor (95% confidence interval). * Statistical significance (p<0.05) compared with control group.

• 

  Figure 2. Graphs demonstrating the value of endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) in the control group and the normal-tension glaucoma (NTG) group. Each dot represents the average of each factor (95% confidence interval). *Statistical significance (p<0.05) compared with control group.

Reference

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