J Korean Ophthalmol Soc.  2009 Jun;50(6):887-892. 10.3341/jkos.2009.50.6.887.

Retinal Nerve Fiber Layer Thickness in Children With Glaucoma

• Kang KD
• Abdul Majid AS
• Kim YD
• Kwag JH
• Yim HB

• KMID: 2212366
• DOI: http://doi.org/10.3341/jkos.2009.50.6.887

Abstract

PURPOSE: To find the optimal parameter of retinal nerve fiber layer (RNFL) analysis in optical coherence tomography (OCT) for diagnosing glaucoma in children.
METHODS
The study was comprised of 127 eyes of 84 patients (aged 6 to 18 years) who visited our institute between March 2006 and February 2008. Subjects were classified into normal, glaucoma suspect and glaucoma groups, and each eye was scanned using Stratus 3.0 OCT. Routine ophthalmic examinations including fundus examination, visual field test and OCT RNFL analysis were performed.
RESULTS
There were 55 normal eyes, 27 glaucoma suspect eyes and 45 glaucomatous eyes. The average RNFL thickness was the most useful parameter to differentiate between the glaucoma and non-glaucoma groups. The next most useful parameter was inferior average thickness, followed by superior RNFL thickness. The sensitivity and specificity of the new discriminant of the formula used were 78%, and 68.6%, respectively.
CONCLUSIONS
In OCT analysis, the average RNFL thickness is the most useful parameter in the diagnosis of glaucoma in children. The new discriminant of the formula is useful in the diagnosis of pediatric glaucoma patients.

Keyword

Children; Optical coherence tomography; Retinal nerve fiber layer analysis

MeSH Terms

Child
Eye
Glaucoma
Humans
Nerve Fibers
Retinaldehyde
Sensitivity and Specificity
Tomography, Optical Coherence
Visual Field Tests
Retinaldehyde

Figure

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  Figure 1. Comparison of mean value between normal, glaucoma suspect and glaucomatous eye using optical coherence tomography retinal nerve fiber layer analysis.

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  Figure 2. ROC (receiver operator characteristic) curve of the discriminant formula.

Reference

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