J Korean Surg Soc.  2010 Nov;79(5):405-410. 10.4174/jkss.2010.79.5.405.

Five-year Survival and Prognostic Factors after Kasai Portoenterostomy for Biliary Atresia

Affiliations
  • 1Department of Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. whp0903@dsmc.or.kr
  • 2Department of Pathology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Abstract

PURPOSE
Long-term survival of biliary atresia patients after Kasai's portoenterostomy is being increasingly reported. Although extended survival has been achieved for many patients, factors influencing outcome have not been defined clearly. The authors investigated 5-year survival rates and prognostic factors for survival after Kasai's portoenterostomy using univariate and multivariable methods.
METHODS
The authors analyzed 5-year survival rates and prognostic factors in 56 patients who underwent Kasai's portoenterostomy during the period from 1991 to 2005 by the Kaplan-Meier model and Cox proportional hazards model, respectively. Both clinical factors and histological features of the liver and periportal fibrous mass were analyzed as prognostic factors.
RESULTS
Younger ages of less than 90 days at surgery, clearance of jaundice and absence of post-Kasai cholangitis in 6 months were predictive of a favorable outcome. A significant difference between the live and the dead was found with regard to an average of 7 or more bile ductules in periportal fibrous mass in 200 HPF (P=0.013). The external diameter of the longest bile ductule in the periportal fibrous mass is not correlated to the prognosis (P=0.49). Independent factors for good prognosis were jaundice-free in 6 months and over 7 bile ductules density in periportal fibrous mass.
CONCLUSION
Favorable outcome after Kasai's portoenterostomy for biliary atresia is determined by bilirubin clearance in 6 months after Kasai operation and seven or more bile ductules in periportal fibrous mass. The 5-year post-Kasai survival rate is 77.2%.

Keyword

Biliary atresia; Kasai procedure; Prognosis; Survival

MeSH Terms

Bile
Biliary Atresia
Bilirubin
Cholangitis
Humans
Jaundice
Liver
Prognosis
Proportional Hazards Models
Survival Rate
Bilirubin

Figure

  • Fig. 1 Cumulative post-Kasai survival curves.

  • Fig. 2 Cumulative post-Kasai survival curves by number of bile ductules (×200 HPF) in periportal fibrous mass.


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