J Korean Assoc Pediatr Surg.  2006 Dec;12(2):202-212.

Kasai Operation for Extrahepatic Biliary Atresia - Survival and Prognostic Factors

• Yoon CS
• Han SJ
• Park YN
• Chung KS
• Oh JT
• Choi SH

Abstract

The prognostic factors for extrahepatic biliary atresia (EHBA) after Kasai portoenterostomy include the patient's age at portoenterostomy (age), size of bile duct in theporta hepatis (size), clearance of jaundice after operation (clearance) and the surgeon's experience. The aim of this study is to examine the most significant prognostic factor of EHBA after Kasai portoenterostomy. This retrospective study was done in 51 cases of EHBA that received Kasai portoenterostomy by one pediatric surgeon. For the statistical analysis, Kaplan-Meier method, Logrank test and Cox regression test were used. A p value of less than 0.05 was considered to be significant. Fifteen patients were regarded as dead in this study, including nine cases of liver transplantation. There was no significant difference of survival to age. The age is also not a significant risk factor for survival in this study (Cox Regression test; p = 0.63). There was no significant difference in survival in relation to the size of bile duct. However, bile duct size was a significant risk factor for survival (Cox Regression test; p = 0.002). There was a significant difference in relation to survival and clearance (Kaplan-Meier method; p = 0.02). The clearing was also a significant risk factor for survival (Cox Regression test; p = 0.001). The clearance of jaundice is the most significant prognostic factor of EHBA after Kasai portoenterostomy.

Keyword

Biliary atresia; Portoenterostomy; Survival; Prognosis

MeSH Terms

Bile Ducts
Biliary Atresia*
Humans
Jaundice
Kaplan-Meier Estimate
Liver Transplantation
Prognosis
Retrospective Studies
Risk Factors