J Periodontal Implant Sci.  2014 Aug;44(4):194-200. 10.5051/jpis.2014.44.4.194.

Comparative study of two collagen membranes for guided tissue regeneration therapy in periodontal intrabony defects: a randomized clinical trial

• Chung YM
• Lee JY
• Jeong SN

• KMID: 2212013
• DOI: http://doi.org/10.5051/jpis.2014.44.4.194

Abstract

PURPOSE
The purpose of this study was to assess and compare the clinical and radiographic outcomes of guided tissue regeneration therapy for human periodontal intrabony defects using two different collagen membranes: a porous nonchemical cross-linking collagen membrane (NC) and a bilayer collagen membrane (BC).
METHODS
Thirty subjects were randomly assigned and divided into the following 3 groups: a test group (NC+BM), in which a NC was used with xenograft bone mineral (BM), a positive control group (BC+BM), in which a BC was used with xenograft BM, and a negative control group (BM), in which only xenograft BM was used. The following clinical measurements were taken at baseline and 3 months after surgery: plaque index, gingival index, probing pocket depth, gingival recession, and clinical attachment level. Radiographic analysis was performed at baseline, 1 week and 3 months after surgery.
RESULTS
Membrane exposure was not observed in any cases. Significant probing depth reduction, attachment-level gain and bone fill were observed for both test and control groups compared to baseline at 3 months after surgery (P<0.05). However, there were no statistically significant differences in clinical improvement and radiographic bone fill between treatment protocols (P>0.05).
CONCLUSIONS
Within the limitations of this study, the results suggest that both NC and BC were comparable in terms of clinical and radiographic outcomes for the treatment of periodontal intrabony defects in human subjects.

Keyword

Chronic periodontitis; Collagen; Guided tissue regeneration

MeSH Terms

Chronic Periodontitis
Clinical Protocols
Collagen*
Gingival Recession
Guided Tissue Regeneration*
Heterografts
Humans
Membranes*
Periodontal Index
Collagen

Figure

• 

  Figure 1 The flow chart of the study. NC: porous nonchemical cross-linking collagen membrane, BC: bilayer collagen membrane, BM: bone mineral.

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  Figure 2 Illustration of radiographic analysis points. CEJ: cemento-enamel junction, AC: alveolar crest, BD: bottom of defect, BG: bone graft material, CEJ-AC: distance between the cement-enamel junction and the alveolar crest, CEJ-BD: distance between the cemento-enamel junction and the bottom of the defect.

• 

  Figure 3 Representative intraoperative photographs of guided tissue regeneration procedure using GuidOss (NIBEC, Jincheon, Korea). (A) A deep intrabony defect on the upper second premolar was detected. The defects and root surfaces were thoroughly planed and debrided. (B) The bone mineral was applied on the intrabony defect. (C) After grafting of bone mineral, a porous nonchemical cross-linking collagen membrane (GuidOss) was trimmed and adapted over the defect. The entire defect and 2-3 mm of the surrounding alveolar bone were completely covered with a membrane. (D) The flap was sutured and completely closed without membrane exposure.

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