J Korean Ophthalmol Soc.  2008 Apr;49(4):677-680. 10.3341/jkos.2008.49.4.677.

A Case of Post-traumatic Necrobiotic Xanthogranuloma of the Orbit

• Choi HJ
• Kwon HJ
• Kim HY

• KMID: 2211502
• DOI: http://doi.org/10.3341/jkos.2008.49.4.677

Abstract

PURPOSE: To investigate the role of nitric oxide (NO) on the migration of cultured human Tenon's capsule PURPOSE: Necrobiotic xanthogranuloma is a very rare disease characterized by the presence of yellow subcutaneous skin lesions and systemic paraproteinemia. We report a case of post traumatic necrobiotic xanthograuloma that presented with a preseptal mass.
CASE SUMMARY
A 31-year-old man presented with ptosis and a mass on the left superior orbit that developed after trauma 3 weeks prior to admission. A computed tomography scan showed a contrast-enhancing preseptal mass, and surgical exploration was performed.
CONCLUSIONS
Histopathological examination revealed a tumor that had all the major features of necrobiotic xanthogranuloma, including fat necrosis with granulomatous inflammation, giant multinucleated cells, foamy cells, and several lymphoid follicles with germinal centers. Hematologic evaluation revealed polyclonal gammopathy.

Keyword

Necrobiotic xanthogranuloma; Orbital tumor; Paraproteinemia; Polyclonal gammopathy

MeSH Terms

Adult
Fat Necrosis
Germinal Center
Humans
Inflammation
Necrobiotic Xanthogranuloma
Nitric Oxide
Orbit
Paraproteinemias
Rare Diseases
Skin
Tenon Capsule
Nitric Oxide

Figure

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  Figure 1. Clinical photograph of a 31-year-old man with 3-week history of ptosis of the left eye.

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  Figure 2. Orbital computed tomography scans showed ill-defined, contrast‐ enhancing mass in the preseptal space (arrows). (A) contrasted, (B) non-contrasted. (preinjection)

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  Figure 3. The granulomatous infiltrate consisted of histiocytes mixed with lymphocytes, foamy cells, multinucleated giant cells, and Touton cells (arrows). (HE stain, original magnifications ×100)

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  Figure 4. One-month postoperative photograph showed no mass lesion or ptosis.

Reference

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