J Pathol Transl Med.  2016 Jan;50(1):75-77. 10.4132/jptm.2015.06.23.

Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis

• Lee S
• Choi HJ

• KMID: 2211409
• DOI: http://doi.org/10.4132/jptm.2015.06.23

Abstract

No abstract available.

MeSH Terms

Angiofibroma*

Figure

• 

  Fig. 1. Ultrasound examination and gross evaluation of orchiectomy specimen. (A) On ultrasound examination, there is an isoechoic mass in the tail area of the epididymis (white arrow). On the cut surface of the gross specimen, solid soft tissue is noted near the tail of the epididymis (A, white arrow) and near the head of the epididymis (B, black arrows).

• 

  Fig. 2. Histopathologic features of the tumor. (A) The tumor is composed of spindle-shaped mesenchymal cells and thick-walled blood vessels. (B) Two mitotic figures per 50 high-power fields are identified in the mass. There is one of the mitotic cells (arrow). (C) A few stromal cells show atypical nuclear morphology.

• 

  Fig. 3. Intratubular microcalcification. There are numerous completely hyalinized ghost tubules with corpus amylacea-like laminated intratubular bodies (arrows).

Reference

1. Nucci MR, Granter SR, Fletcher CD. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1997; 21:636–44.

2. Iwasa Y, Fletcher CD. Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. Am J Surg Pathol. 2004; 28:1426–35.

3. Flucke U, van Krieken JH, Mentzel T. Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Mod Pathol. 2011; 24:82–9.

4. Chen E, Fletcher CD. Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Am J Surg Pathol. 2010; 34:707–14.

5. Sabah M, Mohan P, Kay E. Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient. Virchows Arch. 2006; 449:489–92.

6. Choi HJ, Kim SN, Kim KR. Cellular angiofibroma of the vulva: a report of three cases. Korean J Pathol. 2001; 35:259–62.

7. Arakaki K, Chinen K, Kamiya M, et al. Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report. Int J Clin Exp Pathol. 2014; 7:8972–9.

8. Renshaw AA. Testicular calcifications: incidence, histology and proposed pathological criteria for testicular microlithiasis. J Urol. 1998; 160:1625–8.

9. Zastrow S, Hakenberg OW, Wirth MP. Significance of testicular microlithiasis. Urol Int. 2005; 75:3–7.

10. Fanburg-Smith JC, Devaney KO, Miettinen M, Weiss SW. Multiple spindle cell lipomas: a report of 7 familial and 11 nonfamilial cases. Am J Surg Pathol. 1998; 22:40–8.